#biomarkers

A Nature Neuroscience study links severe multiple sclerosis progression to fat-laden microglia that appear overwhelmed by myelin cleanup, pointing to possible biomarkers and treatment targets.

Researchers say a dual-threshold approach to CA19-9 could identify pancreatic cancer patients with dangerous disease who appear low risk under the standard cutoff because of a genetic nonproducer status.

A Nature Medicine study reports that pairing dermal alpha-synuclein and 4-repeat tau seed amplification assays with serum neurofilament light chain improved differentiation among Parkinson’s disease, multiple system atax

A new ultrasensitive assay developed by Mass General Brigham detects a biomarker tied to FTLD-TDP, a subtype of frontotemporal lobar degeneration that has lacked practical diagnostic tools.

Researchers at MD Anderson Cancer Center report that some relapsed lung cancer cells switch on YAP1 only after chemotherapy, a finding that could help explain why treatment-resistant disease returns.

A new report highlighted by Medical Xpress suggests a brain-based index may help reveal Alzheimer’s risk patterns in adults as young as 30, potentially shifting attention to much earlier stages of risk.

Researchers report that blood measures of biological aging in certain white blood cells tracked cognitive and mood-related symptoms of depression more closely than physical symptoms, pointing toward a more specific bioma

Researchers report that gut “microbial fingerprints” can predict melanoma recurrence after surgery and immunotherapy with accuracy of up to 94%, pointing to a potential new biomarker for post-treatment risk assessment.

A Nature Medicine resource tracked nearly 3,000 plasma proteins in 2,760 women and found broad molecular shifts across the menstrual cycle, including signals tied to reproductive disorders and a 75-protein score that can

Scientists led by Nanyang Technological University, Singapore, report that proteins found in urine can predict which dengue patients are more likely to progress to severe disease, opening the door to simpler risk triage.

Researchers at Örebro University have identified anti-integrin αvβ6 antibodies in blood samples that can flag individuals at risk of developing ulcerative colitis long before any symptoms manifest. The discovery could enable earlier interventions and potentially delay the onset of this debilitating inflammatory bowel disease.

Researchers identify miR-149-5p as a key driver of immune escape in bronchial lesions that can progress to squamous cell lung cancer.

A multi-omics approach achieves 92% accuracy in forecasting organ failure and mortality in trauma patients, days before symptoms appear.

Researchers identify blood-based biomarkers that forecast trauma patient outcomes days before clinical signs appear, transforming critical care.