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neurology Articles | Developments Today

New findings highlight brain changes during menopause

Menopause Triggers Significant Brain Changes, New Study Reveals

Menopause is a critical neurological phase, not just a reproductive milestone.
Resting-state brain activity differs across premenopause, perimenopause, and postmenopause.
Changes are linked to estrogen fluctuations.
Study published in Menopause by University of Vermont researchers.

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DT Editorial Team·Jun 9, 2026·via medicalxpress.com

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Even years after stroke, spinal cord stimulation could improve arm function

Spinal cord stimulation shows new promise for chronic stroke recovery

A pilot trial tested spinal cord stimulation in people with chronic stroke.
Seven participants showed an average 32% increase in arm strength.
Researchers also reported better mobility and less spasticity.
The intervention required fewer than nine hours of training over four weeks.

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DT Editorial Team·Jun 4, 2026·via medicalxpress.com

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Blood test with AI spots four dementia-related brain diseases with 92.3% accuracy

AI blood test separates major dementia disorders in early study

Researchers reported more than 90% accuracy across four major neurodegenerative diseases and healthy aging.
The classifier was designed to detect overlapping disease processes rather than force a single label.
A blood-based approach could be cheaper and easier to scale than more invasive diagnostics.

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DT Editorial Team·May 30, 2026·via medicalxpress.com

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Gut microbiome patterns point to Parkinson’s risk years before diagnosis

Gut microbiome patterns point to Parkinson’s risk years before diagnosis

Nature Medicine says microbiome changes track from healthy people to at-risk and symptomatic groups.
The study suggests some individuals could be flagged years before Parkinson’s symptoms appear.
A healthy diet was inversely associated with the risk-linked microbiome alterations.

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DT Editorial Team·May 30, 2026·via nature.com

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lightning in a dark sky over a field and trees

Study Links Wet, Windy Weather Patterns to Higher Stroke and Brain Hemorrhage Admissions

Researchers analyzed 34,650 neurological emergency cases in Budapest from 2015 to 2019.
Wet, windy and unstable Péczely weather types were linked to higher emergency visits.
The study used a synoptic climatological method rather than single weather variables.
Researchers say vulnerable patients may be affected by combined shifts in pressure, humidity and temperature.

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DT Editorial Team·May 25, 2026·via refractor.io

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DT Editorial Team·May 21, 2026·via newscientist.com

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DT Editorial Team·May 19, 2026·via nature.com

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DT Editorial Team·May 16, 2026·via endpoints.news

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DT Editorial Team·May 13, 2026·via medicalxpress.com

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DT Editorial Team·May 10, 2026·via medicalxpress.com

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DT Editorial Team·May 9, 2026·via medicalxpress.com

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DT Editorial Team·May 9, 2026·via medicalxpress.com

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DT Editorial Team·May 8, 2026·via medicalxpress.com

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DT Editorial Team·May 7, 2026·via endpoints.news

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DT Editorial Team·May 6, 2026·via medicalxpress.com

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DT Editorial Team·May 6, 2026·via medicalxpress.com

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DT Editorial Team·May 5, 2026·via medicalxpress.com

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DT Editorial Team·May 4, 2026·via medicalxpress.com

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DT Editorial Team·Apr 26, 2026·via medicalxpress.com

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DT Editorial Team·Apr 17, 2026·via medicalxpress.com

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Women’s better memories may delay Alzheimer’s diagnosis by years

Women’s Verbal Memory Advantage May Delay Alzheimer’s Diagnosis

Women maintained normal verbal memory test scores for 2.7 years longer than men with similar pathology.
The study analyzed long-term datasets from the U.S. and Canada.
Researchers say stronger baseline verbal memory may mask early decline in women.
The finding has implications for timing of Alzheimer’s diagnosis and treatment.

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A multimodal biomarker strategy to enhance diagnostic precision in neurodegenerative parkinsonism - Nature Medicine

Parkinsonism study combines skin, blood and protein-seeding tests to sharpen diagnosis

A prospective cohort of 166 participants and an external validation cohort of 63 were analyzed.
Dermal alpha-synuclein and 4-repeat tau assays were paired with serum neurofilament light chain.
The combined panel improved discrimination among Parkinson’s disease, multiple system atrophy and progressive supranuclear palsy.

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Encoded

Early Dravet syndrome gene therapy data point to seizure reductions, with major caveats

Encoded Therapeutics reported a 76% seizure reduction in Dravet syndrome.
The supplied excerpt says the result was observed in only three patients.
The data are promising but far too early for broad conclusions.

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Blood-age and genes together may flag dementia risk years earlier

Researchers linked older biological age to higher dementia risk and earlier onset.
Risk was especially high in people with advanced biological aging and two APOE ε4 copies.
The findings support blood-based screening tools aimed at earlier prevention.

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Ultrasensitive TDP-43 Test Could Sharpen Diagnosis for a Hard-to-Identify Dementia

Researchers developed an ultrasensitive assay targeting TDP-43 pathology in FTLD-TDP.
The study found elevated biomarker concentrations correlated with disease severity.
Authors say the work is an early step toward better diagnosis and trial monitoring.

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Severe childhood malaria may leave academic and cognitive effects that last for years

A Ugandan study followed 889 children and adolescents after severe malaria.
Survivors of cerebral malaria and severe malarial anemia showed lower cognitive and academic performance years later.
The findings suggest malaria’s burden includes long-term developmental harm, not only acute illness and death.

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Stroke MRI scans may reveal which patients face the hardest recovery

Researchers reviewed 291 post-stroke scans for signs of blood-brain barrier disruption.
Each 1% increase in disruption was linked to higher odds of poor outcomes after ischemic stroke.
The approach uses MRI information many hospitals already collect, which could ease clinical adoption.

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Brain Imaging Study Points to Distinct Migraine Subtypes

Medical Xpress reports that brain imaging is revealing migraine headache subtypes.
The supplied source text says migraine affects more than one in 10 Americans.
The available material does not include detailed methods or results, limiting stronger conclusions.
Even so, subtype research could matter for diagnosis, trials and personalized treatment.

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Angelini fortifies neurology portfolio with $4.1B buyout of Catalyst Pharma

Angelini Moves to Deepen Rare Neurology Bet With Catalyst Deal

Angelini Pharma is buying Catalyst Pharmaceuticals for $4.1 billion.
The acquisition would add three FDA-approved rare neurology treatments.
The deal strengthens Angelini's existing neurology portfolio rather than opening a new therapeutic area.

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Large Review Finds Newer Migraine Drugs Cut Headache Days With Fewer Side Effects

A large review examined 43 studies on migraine treatment options.
Newer migraine drugs were associated with fewer headache days and fewer side effects.
The findings may improve treatment selection for chronic migraine patients.

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Alzheimer’s Drug Pipeline Expands Beyond Amyloid as Trials Surge

An annual report found a 35% rise in Alzheimer’s clinical trials and a 40% increase in therapies being tested since 2016.
Amyloid-targeting drugs now make up about 20% of the pipeline, down from roughly one-third in 2016.
Inflammation and immune-targeting therapies have grown to 18% of the pipeline, reflecting a broader scientific strategy.

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Researchers map Parkinson’s into two major forms and five subgroups

Researchers grouped Parkinson’s into two broad molecular types and five subgroups.
The study used fruit fly models with Parkinson’s-related mutations and machine-learning analysis.
The findings support a shift toward more personalized therapies instead of one-size-fits-all treatment.

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Exercise Is Emerging as a Core Part of Parkinson’s Care

Research suggests exercise is one of the most effective ways to slow Parkinson’s progression.
The source frames exercise as more than a general health recommendation.
The finding elevates movement as a core part of Parkinson’s care planning.
Accessible interventions can still play a major role in chronic-disease management.

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Preclinical RNA therapy points to a treatment path for an ultrarare neurodevelopmental disorder

St. Jude researchers used an antisense oligonucleotide to suppress aberrant HNRNPH2 in preclinical models.
The treatment also boosted HNRNPH1 expression and reduced multiple symptoms of the disorder.
The work offers mechanistic evidence to support advancement toward clinical studies for an ultrarare disease.

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Researchers say some Alzheimer's movement symptoms may start outside the brain

UCF researchers found evidence that some movement-related Alzheimer's symptoms may originate outside the brain.
The finding could influence future diagnostic approaches.
It may also open new paths for treatment research.

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