#genetics

Researchers using patient-derived tissue and stem-cell models reported that RNA therapy reduced harmful protein aggregation in a form of inherited cardiomyopathy linked to the PLN R14del variant.

California Attorney General Rob Bonta has sued 23andMe, accusing the company of weak security and misleading disclosures after a breach affecting 7 million users.

Researchers say a dual-threshold approach to CA19-9 could identify pancreatic cancer patients with dangerous disease who appear low risk under the standard cutoff because of a genetic nonproducer status.

Researchers at King’s College London report that a measure of biological aging, when paired with APOE genetic risk, can identify people more likely to develop dementia and to develop it earlier.

Researchers at Osaka Metropolitan University found that women with infertility had a higher proportion of blood cells showing loss of the X chromosome, with natural pregnancy odds falling once the proportion rose above a

Researchers at the Technical University of Munich are working on a way to read genetic processes in living cells without destroying them, a step that could make longer-term observation possible.

Researchers testing a single-cell DNA sequencing pipeline unexpectedly found a freshwater protist that appears to reinterpret two genetic stop codons, adding a new exception to one of biology’s foundational rules.

A machine-learning study from VIB and KU Leuven argues that Parkinson’s is not one disease but a family of molecularly distinct disorders, a finding that could reshape how therapies are developed and matched to patients.

Researchers at City of Hope and TGen report a significant correlation between a tumor’s splicing burden and clinical response to treatment in metastatic renal cell carcinoma.

A new PNAS-linked study reports that genetic exchange is widespread across natural populations of Leishmania, challenging the long-held view that the parasites spread mainly through clonal reproduction.

A South Korean team says electromagnetic signals can switch genes on inside cells, but outside critics are challenging the plausibility of the result and pointing to apparent flaws in the published paper.

Researchers have identified a small region on the cannabis X chromosome tied to sex expression and found matching genes in hops, suggesting the mechanism predates the two plants’ split by millions of years.

St. Jude researchers report that an antisense oligonucleotide therapy reversed key features of HNRNPH2-related neurodevelopmental disorder in preclinical models, offering mechanistic support for a move toward human study

The U.S. FDA has approved Regeneron’s Otarmeni, the first gene therapy cleared for hearing loss caused by OTOF mutations, marking a major milestone for genetic medicine and auditory research.

A large genomic analysis of nearly 200 Indigenous people points to three migration waves into South America and indicates that present-day Indigenous Americans retain ancestry from an unidentified Asian source population

A Cell study comparing 190 Alzheimer’s brains with 121 healthy brains found that microglia in Alzheimer’s disease carry recurring mutations in a small set of cancer-driving genes, suggesting some neurodegeneration may be

Researchers report that 10 genes are linked to hyperemesis gravidarum, with one standing out as a likely main driver, offering new evidence that the severe pregnancy condition has a specific biological basis rather than

A team at the Leibniz Institute of Plant Genetics and Crop Plant Research says it has, for the first time, reduced the size of or completely removed chromosomes in wheat, a development that could open new routes for crop

Researchers at the University of Tsukuba report that tomatoes lacking the SlIAA9 gene kept germinating under high temperatures and produced stronger seedlings, offering a new target for breeding heat-resilient crops.

Ancient-DNA analysis has confirmed that two children buried together in Anglo-Saxon England 1,400 years ago were siblings, lending rare biological detail to an unusually intimate grave