#clinical research

All articles tagged with "clinical research"

Low-dose endoxifen shows breast density reductions with fewer side effects in prevention study

A Karolinska Institutet study found that daily low-dose endoxifen reduced mammographic breast density by 19% to 26% in healthy premenopausal women over six months, with fewer side effects than standard tamoxifen.

Key Takeaways

In a six-month study of 240 healthy premenopausal women, 1 mg and 2 mg daily endoxifen both reduced mammographic breast density versus placebo.
Average density reductions were 19% at 1 mg and 26% at 2 mg, compared with prior data showing about 18.5% reduction with 20 mg tamoxifen.

DT Editorial Team·May 4, 2026·via medicalxpress.com

Online Therapy Program Cuts Post-Trauma Stress in Injured Children

A randomized study in JAMA Pediatrics found that an eight-session online program paired with brief therapist check-ins significantly reduced post-traumatic stress symptoms in children recovering from physical injuries.

Key Takeaways

Researchers said nearly half of children with physical trauma develop lasting post-traumatic stress symptoms.
The eight-session ReSeT program combines short interactive videos with therapist check-ins.

DT Editorial Team·Apr 30, 2026·via medicalxpress.com

Daily Toothbrushing in Hospital Cut Pneumonia Risk in Large Randomized Trial

A large randomized controlled trial in Australian hospitals found that patients given toothbrushes, toothpaste and oral-care guidance were far less likely to develop hospital-acquired pneumonia.

Key Takeaways

A randomized trial across three Australian hospitals involved 8,870 patients.
Patients given toothbrushes, toothpaste and oral-care advice were 60 percent less likely to develop hospital-acquired pneumonia.

DT Editorial Team·Apr 20, 2026·via newscientist.com

Study summary points to standard-dose amoxicillin-clavulanate for uncomplicated acute sinusitis

A retrospective report highlighted by Medical Xpress says standard-dose amoxicillin-clavulanate emerged as the preferred treatment choice for uncomplicated acute sinusitis, a common reason U.S. adults receive antibiotics

DT Editorial Team·Apr 18, 2026·via medicalxpress.com