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© 2026 Developments Today. All rights reserved.

medical research Articles | Developments Today

Drug-coated balloons could offer an alternative to permanent heart stents for some patients

Drug-Coated Balloons Match Stents on Major Heart Outcomes

Analysis pooled 10 randomized trials involving 7,832 patients.
Major cardiovascular death and heart-attack outcomes were comparable with stents.
Drug-coated balloon recipients may be more likely to need a repeat procedure.

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DT Editorial Team·Oct 16, 2026·via medicalxpress.com

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A closer look at endometriosis pain: New map reveals key cellular interactions

Endometriosis Pain Map Reveals Neuron-Immune Links

JAX researchers mapped cell types within human endometriosis lesions.
Several sensory-neuron types were found clustered near lesion cores.
The study examines how neuron and immune-cell interactions may amplify pain signaling.

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DT Editorial Team·Oct 14, 2026·via medicalxpress.com

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Popular weight loss drugs linked to a surprising fingernail problem

Study links GLP-1 medicines to nail, hair and scalp problems

The study compared 575 GLP-1 users with 1,329 people with obesity and/or type 2 diabetes who had not used the drugs.
Thirty-nine percent of GLP-1 users reported nail detachment, compared with 9% of controls.
Two-thirds of GLP-1 users reported at least one nail disorder, versus 53% of controls.
The findings are an association presented at EADV 2026 and do not prove that GLP-1 medicines caused the symptoms.

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DT Editorial Team·Oct 13, 2026·via sciencedaily.com

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Bones, Liver, And Blood Fats All Shift Abruptly at Menopause, Huge Study Finds : ScienceAlert (via www.sciencealert.com)

Menopause study finds a sharp physiological shift at final period

Researchers reconstructed menopause-linked laboratory trajectories from two independent cohorts.
The analysis found step-like changes at the final menstrual period across endocrine, skeletal, hepatic, renal and lipid systems.
Dysregulation began more than a decade before the final menstrual period and was attenuated in hormone therapy users.

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DT Editorial Team·Oct 13, 2026·via nature.com

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The eye has a hidden cleanup system scientists never knew existed

Scientists Identify a New Waste-Drainage Route in the Eye

Researchers identified a route called posterior ocular lymphatic outflow, or POLO.
The route was demonstrated in mice and appears to move fluid and waste from the back of the eye into the lymphatic system.
The finding could guide research into glaucoma, macular degeneration and other vision-threatening conditions, but it is not yet a treatment.

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DT Editorial Team·Oct 11, 2026·via sciencedaily.com

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Aspirin rarely used for colorectal cancer prevention

Lower-Dose Aspirin May Expand Cancer Prevention Options for Lynch Syndrome

A survey of 539 people with Lynch syndrome found 10.4% were taking aspirin.
Earlier CAPP2 research linked 600 mg daily aspirin to lower long-term colorectal cancer risk.
CaPP3 suggests 100 mg daily could provide similar prevention with fewer bleeding complications, though interpretation remains cautious.

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DT Editorial Team·Oct 11, 2026·via medicalxpress.com

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Radiation exposure linked to pulmonary hypertension after lung cancer treatment

Radiation Dose to Pulmonary Artery Linked to Hypertension Risk

The study examined patients receiving chest radiation for lung cancer at three institutions.
Pulmonary hypertension was associated with radiation dose to the pulmonary artery.
Twelve percent of evaluated patients experienced pulmonary hypertension.
The authors call for greater awareness, risk assessment guidance and further research.

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DT Editorial Team·Oct 10, 2026·via medicalxpress.com

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AI-assisted scoping review of code sharing in clinical prediction model research | Nature Medicine (via www.nature.com)

Clinical prediction studies still rarely share usable code

Researchers screened 3,967 articles citing TRIPOD or TRIPOD+AI.
Only 482 articles, or 12.2%, included code-sharing statements.
Repository quality varied in documentation, dependencies and executable structure.
The findings will inform the TRIPOD-Code reporting guideline.

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DT Editorial Team·Oct 10, 2026·via nature.com

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Olive oil-based lotion could simplify scabies treatment by clearing mites and eggs with a single application

Olive oil lotion clears scabies mites and eggs in pig study

The lotion combines abametapir, which targets egg hatching, with flavesone, which kills adult mites.
A four-hour single application cleared live mites and viable eggs within 24 hours in pigs.
The study is preclinical and does not yet demonstrate safety or effectiveness in humans.

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DT Editorial Team·Oct 9, 2026·via medicalxpress.com

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Does your sleep tracker get it right? A neuroscientist weighs in

Sleep Tracker Accuracy: A Neuroscientist on What Wearables Miss

A 2025 meta-analysis of 24 studies and nearly 800 participants found wearables overestimate total sleep time by about 17 minutes per night compared with polysomnography.
The main blind spot is quiet wakefulness: lying still and awake is often misinterpreted as sleep, which disproportionately affects people with insomnia.
Wearables do not measure brain waves directly, so sleep-stage estimates (REM, deep sleep) are inferred from movement and heart rate rather than measured clinically.
Apple's newest watch introduces a morning readiness score and claims the most accurate heart-rate tracking, but these claims have not been independently verified.

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DT Editorial Team·Oct 6, 2026·via medicalxpress.com

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Gender medicine: effects of sex and gender on cardiovascular disease manifestation and outcomes | Nature Reviews Cardiology (via www.nature.com)

Sex and Gender Differences Belong in Treatment Guidelines, Nature Medicine Argues

A Nature Medicine commentary published 23 September 2026 argues that sex and gender differences belong in clinical treatment guidelines.
The piece says guidelines should state what is already known, identify where evidence is missing, and specify what future trials must report.
Sex and gender are distinct concepts, and conflating them obscures whether observed differences arise from biology, care patterns or both.
The commentary frames guideline writing and trial reporting as connected problems, since panels can only work with the evidence trials produce.

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DT Editorial Team·Sep 25, 2026·via nature.com

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Endometriosis can elude diagnosis for years. What to know about the disease and new ways to find it

Endometriosis Can Elude Diagnosis for Years: What to Know

Patient Zoë Armstrong waited years for a diagnosis; an ultrasound report finally confirmed endometriosis.
The American College of Obstetricians and Gynecologists says people can wait a decade or more for diagnosis.
Endometriosis affects 1 in 10 women worldwide and can cause debilitating pain, fatigue, bloating and infertility.
New tests used in other countries are raising hopes but are not yet available in the U.S., and experts say they won't be a complete solution.

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DT Editorial Team·Sep 6, 2026·via medicalxpress.com

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Silent artery plaques may appear in one in 13 adults before age 30

Silent artery plaques found in many adults under 30

Atherosclerotic plaques were found in 57.1% of more than 16,000 symptom-free participants.
The study suggests silent plaque may already be present in roughly one in 13 adults before age 30.
Researchers say earlier identification could reshape cardiovascular prevention toward direct disease detection.

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DT Editorial Team·Aug 29, 2026·via medicalxpress.com

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New brain map connects mice and primates to strengthen medical research

New Cross-Species Brain Map Bridges Mice and Marmosets to Boost Medical Research

Researchers built the first cross-species brain map linking mouse and marmoset regions.
The map overcomes inconsistencies in existing brain atlases by focusing on leaf-level regions.
Marmosets serve as a bridge between mice and humans for neuroscience research.
This tool could improve translation of animal model findings to human medicine.

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DT Editorial Team·Aug 13, 2026·via medicalxpress.com

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Non-Invasive Tests for the Detection of MASLD: Biomarkers and Imaging for Staging Steatosis, MASH, and Fibrosis - PMC (via pmc.ncbi.nlm.nih.gov)

Non-invasive liver scans show potential to replace some biopsies in MASLD

A Nature Medicine research briefing summarizes results from the LITMUS imaging study in MASLD.
Elastography and elastography-based composite scores showed enough accuracy to evaluate advanced fibrosis and cirrhosis.
The study found that current markers were not accurate enough to diagnose MASH without biopsy.
The findings support a more targeted role for liver biopsy rather than full replacement across all MASLD assessments.

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DT Editorial Team·Aug 4, 2026·via nature.com

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End-to-end multimodal pathology foundation model with clinical dialogue - Nature Medicine

PRISM2 links pathology slides with clinical dialogue

Nature Medicine published PRISM2, a multimodal pathology foundation model trained on 2.3 million whole-slide images.
The model used 14 million question-answer pairs derived from 700,000 pathology reports for clinical dialogue supervision.
The paper reports clinical-grade or better balanced accuracy in several cancer detection tasks and strong transfer performance across benchmarks.

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DT Editorial Team·Aug 3, 2026·via nature.com

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New mechanism explains how spinal stimulation improves arm movement after stroke

How Spinal Cord Stimulation May Restore Smoother Arm Movement After Stroke

A new study ties post-stroke arm improvement from spinal stimulation to restored inhibitory spinal circuits.
The mechanism centers on reciprocal inhibition, which helps opposing muscles coordinate smoothly.
The finding could support more personalized neurorehabilitation strategies.

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DT Editorial Team·Jul 17, 2026·via medicalxpress.com

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Ways to make clinical trials more informative and reduce research waste

Researchers Outline Practical Fixes for Wasteful Clinical Trials

A JAMA Network Open study gathered views from 55 stakeholders across 16 countries.
Participants broadly agreed on stronger pre-funding review, better recruitment planning, improved team training, and deeper patient involvement.
The INFORM project argues many trials fail to produce useful evidence and that much of this waste is preventable.

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DT Editorial Team·Jul 1, 2026·via medicalxpress.com

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Researchers discover new driver of asthma-related inflammation

Asthma Study Identifies CBX7 as a New Inflammation Driver

Researchers identified CBX7 as a newly recognized driver of allergic asthma inflammation.
The protein appears to act both in the cytoplasm and nucleus to sustain cytokine production.
Reducing CBX7 activity lowered inflammatory cytokine output in immune cells.
The findings point to a possible future therapeutic target, but not an immediate treatment.

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DT Editorial Team·Jun 26, 2026·via medicalxpress.com

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Therapeutic target for dangerous fungal infections identified

Candida auris weak point offers a new path for antifungal drugs

Researchers identified TRK1 as essential for Candida auris growth.
The gene is also required for colonization of human skin.
The discovery could support new therapies against a drug-resistant hospital pathogen.

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DT Editorial Team·Jun 17, 2026·via medicalxpress.com

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