#metabolism

Researchers report that a metabolite-linked pathway helps some ovarian tumors repair DNA damage and survive platinum chemotherapy, revealing a potential way to weaken treatment resistance.

Researchers at Helmholtz Munich have built a hybrid obesity therapy that uses GLP-1 and GIP signaling to deliver a second metabolic drug into target cells, producing stronger weight-loss and glucose effects in mice.

New work reported in Cell Metabolism suggests hormone-sensitive lipase has a second role inside adipocyte nuclei, helping explain why loss of the protein leads to lipodystrophy rather than obesity.

Drexel University researchers report a critical metabolic vulnerability in breast cancer that has spread to the brain, pointing toward a possible therapeutic target for one of oncology’s hardest problems.

A Nature study in mice suggests low-protein diets can trigger gut microbe-driven signals that turn white fat toward a calorie-burning beige state, revealing a complex microbiome link in metabolism.

Researchers at the University of Oklahoma report that FGF21 reverses obesity in mice by acting through a hindbrain circuit linked to metabolism, pointing to a pathway distinct from appetite-suppressing GLP-1 drugs.