#clinical trials

A new FDA effort aims to use AI and real-time monitoring to reduce delays between clinical trial phases and compress parts of the drug development timeline.

The FDA has launched a pilot to review clinical trial data as it is generated, giving agency scientists earlier access to information from ongoing studies.

Intellia has reported what the source material describes as the first Phase 3 success for an in vivo CRISPR therapy, a milestone that could move gene editing inside the body closer to regulatory approval.

A pilot trial reported that selectively removing circulating sFlt-1 in women with very preterm preeclampsia was feasible, appeared safe in the study setting, and was associated with modest blood-pressure reductions.

An analysis of two major clinical trials suggests imaging can reveal metastatic prostate cancer progression even when standard biomarkers remain unchanged during treatment.

A new review of 15 clinical trials adds to evidence that psilocybin may help treat depression, especially for patients not well served by standard therapies, while underscoring how early the field still is.

Isomorphic Labs says it is preparing to enter the clinic with drugs designed using AlphaFold-based AI tools, bringing one of the boldest promises in AI drug discovery closer to a real-world test.

A Nature Medicine feature describes how a trial built around one baby is becoming a practical example of patient-driven research moving from exception to model.

An investigational antibody-drug conjugate targeting CLDN6 showed clinical activity in heavily pretreated patients with advanced platinum-resistant ovarian cancer, according to phase 1 data presented at AACR 2026.

A randomized phase 2 trial in Nature Medicine found that adding elraglusib to gemcitabine plus nab-paclitaxel improved median overall survival and one-year survival in previously untreated metastatic pancreatic ductal ad

An experimental gene-silencing drug reduced a Parkinson’s-linked protein by as much as 60% in an early human study, offering a measurable biological signal while leaving larger questions about clinical benefit for later,

A large trial in India found two new tuberculosis vaccines were safe in adults and children, but neither delivered broad protection against all forms of TB.

A phase 1 trial in Nature Medicine reports that zodasiran, an ANGPTL3-targeting small interfering RNA, lowered triglycerides and sharply reduced circulating ANGPTL3 across multiple dyslipidemia groups without serious and

Two phase 3 EVOKE(+) trials found that semaglutide did not slow clinical progression in Alzheimer’s disease, despite earlier signals that GLP-1 drugs might help.

Merck says it is leaning toward a lower Winrevair dose in a planned Phase 3 study for an uncommon form of heart failure after seeing what its chief medical officer called a profound benefit at the lowest dose tested in a

A small phase 1 study in relapsed or refractory multiple myeloma reports that anti-BCMA CAR-T cells can be generated inside the body after a single infusion, potentially bypassing several steps that usually slow access.

AI models are evolving from research assistants into genuine scientific co-investigators, with hypotheses now being validated in organoids, animal models, and early-stage clinical trials, according to Nature Medicine.

A Nature Medicine review traces the rapid advance of personalized mRNA cancer vaccines from experimental concept to active clinical development, marking a turning point for cancer immunotherapy.

Structure Therapeutics reports encouraging Phase 2 results for its oral GLP-1 receptor agonist, advancing a pill-form alternative to injectable weight-loss and diabetes drugs.

Three landmark clinical trials confirm that fecal microbiota transplantation can significantly enhance the effectiveness of immunotherapy in advanced solid tumors.