#depression

A new global analysis finds mental health disorders are now the leading cause of disability worldwide, with anxiety and depression rising sharply since the pandemic.

A small randomized trial found that a single psilocybin dose reduced depression symptoms within days and outperformed placebo for more than three months on self-rated outcomes, though participants usually guessed what họ

A major global analysis found that nearly 1.2 billion people were living with a mental disorder in 2023, with anxiety and depression driving a steep rise since the pandemic era.

NYU researchers say a simple apple-harvesting game distinguished people with major depression from healthy controls and tracked illness severity by measuring how players responded to declining rewards.

A small randomized trial suggests the anti-inflammatory drug tocilizumab may ease symptoms in people with moderate-to-severe depression who have not improved on standard antidepressants, adding fresh weight to the idea a

A study published in JAMA Psychiatry found that semaglutide significantly improved measures of motivation in patients with major depressive disorder, pointing to a potentially important new line of investigation beyond a

Two new JAMA Psychiatry analyses suggest existing medicines may help patients whose depression has not improved after standard treatment, with intravenous ketamine showing rapid short-term effects and combination therapy

Researchers report that blood measures of biological aging in certain white blood cells tracked cognitive and mood-related symptoms of depression more closely than physical symptoms, pointing toward a more specific bioma

A new Cell study identifies a specific subset of opioid receptors on prefrontal cortex interneurons as a key part of ketamine’s rapid antidepressant action, opening the door to more targeted therapies.

A new report says an algorithm may identify people headed toward self-harm before obvious signs appear, pointing to earlier intervention possibilities in mental-health care.

A Harvard Medical School team reports that Morganella morganii can produce an inflammation-triggering molecule when it interacts with an environmental contaminant, offering a clearer mechanism linking the gut microbiome,

A new review of 15 clinical trials adds to evidence that psilocybin may help treat depression, especially for patients not well served by standard therapies, while underscoring how early the field still is.

A new study argues that depression screening can become more accurate and easier for patients by letting them answer in natural language instead of relying only on standardized rating scales.