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metabolism Articles | Developments Today

Scientists identify metabolic target to overcome chemotherapy resistance in ovarian cancer

Ovarian cancer study points to a metabolic weak spot in chemo resistance

Researchers linked chemotherapy resistance in some ovarian cancers to a metabolic pathway involving alpha-ketoglutarate.
The study identified TMLHE as an enzyme connected to tumor DNA repair capacity.
The findings suggest an existing drug may help weaken resistance when paired with chemotherapy.

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DT Editorial Team·May 28, 2026·via medicalxpress.com

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New “Trojan horse” obesity drug supercharges weight loss in early tests

A ‘Trojan horse’ obesity drug outperforms standard comparators in mice

Researchers linked an incretin compound to lanifibranor in one hybrid molecule.
The treatment improved appetite, weight, and glucose outcomes in mice.
The study remains preclinical and does not yet establish human efficacy or safety.

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DT Editorial Team·May 9, 2026·via sciencedaily.com

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New obesity discovery rewrites decades of fat science

Researchers Say a Fat-Burning Protein Also Protects Fat Cells From Within the Nucleus

Researchers reported that hormone-sensitive lipase operates inside adipocyte nuclei as well as on lipid droplets.
The finding may explain why HSL loss leads to lipodystrophy rather than obesity in mice and people with mutations.
The work could reshape how scientists think about adipocyte health and metabolic disease.

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DT Editorial Team·May 9, 2026·via sciencedaily.com

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Researchers identify a metabolic weakness in breast cancer brain metastases

Drexel University researchers identified a metabolic vulnerability in breast cancer that has spread to the brain.
The finding points to a possible therapeutic target rather than an approved treatment.
The work could help focus future research on the biology of brain metastases.

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DT Editorial Team·Apr 22, 2026·via medicalxpress.com

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A low-protein diet isn't normally associated with weight loss, but a new study might cause researchers to look at this way of eating in a different light

Mouse study links low-protein diets, gut microbes, and fat-burning tissue

A mouse study found that low protein intake can trigger fat browning through gut microbes.
Two signaling routes, involving FXR and FGF21, were highlighted.
The work suggests therapeutic possibilities but remains far from a human-ready intervention.

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DT Editorial Team·Apr 17, 2026·via refractor.io

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DT Editorial Team·Apr 17, 2026·via sciencedaily.com

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Scientists discover natural hormone that reverses obesity

Natural Hormone Reversed Obesity in Mice by Activating an Unexpected Brain Circuit

University of Oklahoma researchers traced FGF21’s action to the hindbrain rather than the hypothalamus.
The study says the hormone works through the nucleus of the solitary tract, area postrema, and parabrachial nucleus.
FGF21 appears to drive energy burning instead of primarily reducing appetite.
The pathway is already of interest because related drugs are being tested for MASH.

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