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Depression treatment during pregnancy may benefit babies' brain development, randomized trial finds

Prenatal Depression Therapy Linked to Infant Brain Changes

A randomized trial tested psychotherapy for depression during pregnancy.
Infants in the treatment group showed differences in a brain region tied to emotion and memory.
Those brain differences were associated with lower negative emotionality in infancy.

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DT Editorial Team·Oct 16, 2026·via medicalxpress.com

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Contrary to fears, psilocybin users with depression continue to seek treatment

Psilocybin Users With Depression Still Seek Mental Health Care, Study Finds

A UC San Diego School of Medicine study found that people with depression who use psilocybin seek mental health care at rates similar to nonusers.
The research, published in Psychological Medicine, analyzed 2024 National Survey on Drug Use and Health data — the first NSDUH iteration to track how recently respondents used psilocybin.
The sample covered 6,793 people ages 12 and older who reported a past-year major depressive episode, with an estimated 7.3% reporting psilocybin use.
Psilocybin users reported higher unmet needs for mental health services, suggesting the compound is used as an alternative or adjunct rather than a replacement for conventional care.

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DT Editorial Team·Oct 7, 2026·via medicalxpress.com

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Insomnia linked to higher risk of stroke

Insomnia Linked to 26% Higher Stroke Risk, Review Finds

A review in Sleep Medicine Reviews found insomnia is associated with a 26% higher risk of stroke (HR 1.26; 95% CI 1.05–1.53).
People with insomnia had 28% higher odds of hospital admission for any reason (OR 1.28).
Insomnia was also linked to depression and suicidal behaviours, with suggested links to dementia, particularly Alzheimer's disease.
The review combined existing systematic reviews with three new ones covering stroke, occupational injuries and hospitalisation, drawing on over 1.3 million participants across seven health outcomes.

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DT Editorial Team·Sep 28, 2026·via medicalxpress.com

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Ketamine reveals shifting brain activity patterns linked to depression improvement in older adults

Ketamine Reveals Shifting Brain Activity Patterns in Older Adults With Depression

Texas A&M researchers identified time-specific brain activity patterns after ketamine treatment in older adults with treatment-resistant depression.
The findings, published in Translational Psychiatry, may help identify biological markers of ketamine's antidepressant effects.
The EPMAD Lab is studying U.S. veterans older than 55, a group often excluded from ketamine research due to safety and efficacy concerns.
Dr. Nicholas Murphy compares ketamine to opening a floodgate that increases brain flexibility and connectivity.

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DT Editorial Team·Sep 12, 2026·via medicalxpress.com

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Dysregulated adult hippocampal neurogenesis in major depressive disorders | Nature Medicine (via www.nature.com)

Stalled Neurogenesis in Major Depression: Largest Human Hippocampus Atlas Reveals New Targets

Study constructs the largest multiomic atlas of the adult human hippocampus from nonmedicated MDD individuals and controls.
Identifies a neurogenic lineage in the subgranular zone and shows evidence of a stalled neurogenic process in MDD.
Stalling is associated with transcriptional regulation, stress-related reprogramming, and interferon signaling across developmental stages.
Excitatory and inhibitory neurons show dysregulated transcription factor networks affecting cell states.

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DT Editorial Team·Aug 23, 2026·via nature.com

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New brain cell formation stalls in adults with depression, study shows

Depression Linked to Stalled Brain Cell Formation in Adults, Study Finds

Researchers analyzed nearly 500,000 hippocampal cells from depressed and non-depressed individuals.
Neurogenesis, the production of new neurons, stalls in the brains of adults with major depressive disorder.
The study identifies molecular programs controlling neurogenesis as potential therapeutic targets.
Depression is framed not just as serotonin deficiency but as a failure of neural plasticity.

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DT Editorial Team·Aug 21, 2026·via medicalxpress.com

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Trouble focusing when upset may signal anxiety and depression symptoms in youth

Emotional Focus in Children Linked to Anxiety and Depression Risk

Study validates self-report survey for children measuring emotional focusing and shifting.
Children who struggle to focus when upset are more likely to have anxiety or depression.
Teenagers show more difficulty with emotional focus than younger children, contrary to expectations.
High-achieving students may hide distress, making early detection challenging.

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DT Editorial Team·Aug 16, 2026·via medicalxpress.com

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Woman open curtains in a dark room (via kcl.ac.uk)

Psilocybin-Assisted Therapy Shows Promise for Treatment-Resistant Depression in NHS Trial

Randomized controlled trial in NHS England with 60 adults with treatment-resistant major depressive disorder.
Psilocybin-assisted therapy led to significant reduction in depressive symptoms compared to placebo.
No serious adverse events; safety profile acceptable.
Findings suggest feasibility of psychedelic therapy in public healthcare settings.

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DT Editorial Team·Aug 7, 2026·via nature.com

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Global economic burden of depression in 154 countries from 2025 to 2050 - Nature Medicine

Depression Could Cost the Global Economy $12 Trillion by 2050

Researchers modeled depression’s macroeconomic effects across 154 countries from 2025 to 2050.
The baseline estimate puts the global burden at US$12 trillion in 2024 dollars.
Lower labor force participation and reduced productivity are the main cost drivers.
Including suicide-related deaths in an upper-bound scenario raises the estimate to US$14 trillion.

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DT Editorial Team·Aug 1, 2026·via nature.com

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Nordic walking significantly reduces depression symptoms in as little as five weeks, trial finds

Nordic Walking Trial Shows Fast Depression Benefit

A randomized controlled trial enrolled 64 adults with moderate to severe depression.
Ten weeks of supervised Nordic walking outperformed a non-exercise control.
Most symptom improvement was reported within the first five weeks.

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DT Editorial Team·Jun 20, 2026·via medicalxpress.com

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Parkinson's medication shows promise in treating treatment-resistant depression

Parkinson’s drug shows promise for resistant depression

A nine-week trial tested pramipexole as an add-on therapy for treatment-resistant depression with marked anhedonia.
Patients receiving pramipexole improved more than the placebo group.
Brain imaging suggested effects on reward-related ventral striatal activity.

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DT Editorial Team·Jun 12, 2026·via medicalxpress.com

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GLP-1s may alleviate depression through the microbiome, mouse study suggests

GLP-1 Drugs May Ease Depression via Gut Microbiome, Mouse Study Finds

Liraglutide accumulated in the intestine, not the brain, in stressed mice.
Antidepressant effects persisted in mice with GLP-1 receptors knocked out.
Depleting gut microbiota with antibiotics eliminated the antidepressant effect.
Lactobacillus delbrueckii increased significantly and produces a precursor to the endocannabinoid 2-AG.

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DT Editorial Team·Jun 10, 2026·via medicalxpress.com

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Mental health disorders become top global disability cause as cases near 1.2 billion

Mental health disorders become the world’s leading disability burden

A global analysis found nearly 1.2 billion people lived with a mental health disorder in 2023.
Researchers said mental health disorders are now the leading cause of disability worldwide.
Major depressive disorder and anxiety disorders both rose sharply after 2019.
The burden peaks among people aged 15 to 19 and disproportionately affects women.

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DT Editorial Team·Jun 1, 2026·via medicalxpress.com

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A single dose of psilocybin eased depression symptoms for months, our study found

Psilocybin Showed Fast Antidepressant Effects in a Small Trial, but Blinding Remains a Major Problem

A randomized trial found that psilocybin reduced depression symptoms within days and outperformed placebo over the short term.
More than half of the psilocybin group no longer met depression criteria after six weeks, versus one person in the placebo group.
Most participants correctly guessed which treatment they received, highlighting a major methodological issue in psychedelic research.

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DT Editorial Team·May 22, 2026·via medicalxpress.com

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Mental disorders have nearly doubled since 1990, now affecting 1.2 billion people worldwide

Mental Disorders Now Rank as the World’s Leading Cause of Disability

A global study found nearly 1.2 billion people were living with a mental disorder in 2023.
Mental disorders now account for the largest share of disability worldwide.
Anxiety and major depressive disorder have risen sharply since 2019.
Adolescents aged 15 to 19 and women are disproportionately affected.

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DT Editorial Team·May 22, 2026·via medicalxpress.com

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This 3-Minute Video Game Is Surprisingly Good at Spotting Depression

A Three-Minute Smartphone Game Could Become a New Screen for Depression

NYU researchers created a three-minute game to detect anhedonia, a common feature of depression.
Players with major depression switched away from declining rewards earlier than healthy controls.
The team says game behavior also tracked with illness severity and is pursuing FDA clearance.

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DT Editorial Team·May 20, 2026·via gizmodo.com

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Pilot trial points to immune-targeted therapy for hard-to-treat depression

A 30-person pilot trial tested tocilizumab in moderate-to-severe depression that had not responded to standard antidepressants.
Compared with placebo, the anti-inflammatory drug appeared to reduce depression symptoms and improve fatigue, anxiety, and quality of life.
The study adds clinical support to the idea that an IL-6-linked inflammatory pathway may drive a subset of depression cases.

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DT Editorial Team·May 20, 2026·via medicalxpress.com

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Semaglutide study links diabetes drug to improved motivation in major depressive disorder

A study published in JAMA Psychiatry found semaglutide significantly improved measures of motivation in patients with major depressive disorder.
The reported effect focuses on motivation, a clinically important symptom domain in depression.
The supplied source does not provide trial size, effect size, or treatment protocol details, so the finding remains an early but notable signal.

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DT Editorial Team·May 14, 2026·via medicalxpress.com

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Existing drug combinations show new promise for treatment-resistant depression

Researchers reviewed 26 randomized controlled trials of intravenous ketamine.
Ketamine outperformed placebo over the short term and appeared comparable to esketamine.
Both ketamine and esketamine were reported to rapidly reduce suicidal impulses in acute cases.

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DT Editorial Team·May 10, 2026·via medicalxpress.com

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A Blood-Aging Signal May Help Explain Why Depression Does Not Look the Same in Everyone

Researchers linked a blood-based aging signal to cognitive and mood-related depression symptoms.
The finding was highlighted in work involving women with HIV, who face elevated depression risk.
The result points toward more specific biomarkers rather than a single universal depression test.

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DT Editorial Team·May 4, 2026·via medicalxpress.com

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