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Tumor Antioxidants Suppress T Cell Immunity by Scavenging Reactive Oxygen Species
Key Takeaways
- A Science-published study shows tumors secrete antioxidants that neutralize ROS in the tumor microenvironment.
- T cells need reactive oxygen species as signaling molecules for activation, a function previously underappreciated.
- Depletion of ROS by tumor-derived antioxidants suppresses T-cell responses and promotes immune evasion.
- Blocking antioxidant secretion restores T-cell activity in experimental models, suggesting a new cancer therapy angle.
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DT Editorial Team··via science.org