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#Parkinson's disease

All articles tagged with "Parkinson's disease"

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Parkinson's disease Articles | Developments Today

Parkinson's medication shows promise in treating treatment-resistant depression

Parkinson’s drug shows promise for resistant depression

A nine-week trial tested pramipexole as an add-on therapy for treatment-resistant depression with marked anhedonia.
Patients receiving pramipexole improved more than the placebo group.
Brain imaging suggested effects on reward-related ventral striatal activity.

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DT Editorial Team·Jun 12, 2026·via medicalxpress.com

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Phase 1 Trial Shows Dual-Target Gene Therapy Safe for Parkinson's Disease

Phase 1 Trial Shows Dual-Target Gene Therapy Safe for Parkinson's Disease

Phase 1 trial of BBM-P002, a dual-target gene therapy co-delivering TH and AADC, shows safety and tolerability in 10 patients with moderate-to-advanced Parkinson's disease.
No dose-limiting toxicities or drug-related serious adverse events were reported; 23 mild, transient adverse events were deemed unrelated to treatment.
The therapy aims to enable autonomous dopamine synthesis, potentially reducing dependence on levodopa.
Results support continued clinical development; efficacy data are pending.

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DT Editorial Team·Jun 10, 2026·via nature.com

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Gut microbiome patterns point to Parkinson’s risk years before diagnosis

Gut microbiome patterns point to Parkinson’s risk years before diagnosis

Nature Medicine says microbiome changes track from healthy people to at-risk and symptomatic groups.
The study suggests some individuals could be flagged years before Parkinson’s symptoms appear.
A healthy diet was inversely associated with the risk-linked microbiome alterations.

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DT Editorial Team·May 30, 2026·via nature.com

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Biogen, Denali to drop drug in non-genetic Parkinson’s after mid-stage study flop

Biogen and Denali Pull Back a Parkinson’s Program After a Mid-Stage Failure

Biogen and Denali’s LRRK2 inhibitor failed a Phase 2b study in early Parkinson’s disease.
The companies are dropping the program in certain patients with non-genetic Parkinson’s.
The supplied source text does not provide detailed study data, but it clearly establishes a strategic pullback.

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DT Editorial Team·May 24, 2026·via endpoints.news

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A multimodal biomarker strategy to enhance diagnostic precision in neurodegenerative parkinsonism - Nature Medicine

Parkinsonism study combines skin, blood and protein-seeding tests to sharpen diagnosis

A prospective cohort of 166 participants and an external validation cohort of 63 were analyzed.
Dermal alpha-synuclein and 4-repeat tau assays were paired with serum neurofilament light chain.
The combined panel improved discrimination among Parkinson’s disease, multiple system atrophy and progressive supranuclear palsy.

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DT Editorial Team·May 19, 2026·via nature.com

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DT Editorial Team·May 5, 2026·via medicalxpress.com

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DT Editorial Team·May 4, 2026·via medicalxpress.com

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DT Editorial Team·Apr 11, 2026·via medicalxpress.com

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DT Editorial Team·Mar 16, 2026·5 min read·via phys.org

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Researchers map Parkinson’s into two major forms and five subgroups

Researchers grouped Parkinson’s into two broad molecular types and five subgroups.
The study used fruit fly models with Parkinson’s-related mutations and machine-learning analysis.
The findings support a shift toward more personalized therapies instead of one-size-fits-all treatment.

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Exercise Is Emerging as a Core Part of Parkinson’s Care

Research suggests exercise is one of the most effective ways to slow Parkinson’s progression.
The source frames exercise as more than a general health recommendation.
The finding elevates movement as a core part of Parkinson’s care planning.
Accessible interventions can still play a major role in chronic-disease management.

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Experimental Parkinson’s drug posts early signal by lowering linked protein in first human trial

First-in-human trial reported encouraging effects.
Experimental drug is designed to silence a gene strongly linked to Parkinson’s disease.
Study said the therapy cut a Parkinson’s-linked protein by up to 60%.
Findings were reported in Nature Medicine.

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Bacteria Transform Plastic Bottles into Parkinson's Drug

Engineered bacteria break down PET plastic from water bottles and synthesize levodopa, the primary Parkinson's drug
The pathway connects PET degradation products to the shikimate pathway and levodopa biosynthetic route
Circular economy potential: plastic waste as feedstock for a pharmaceutical with established global demand
Research is proof-of-concept stage; yield optimization and regulatory compliance remain ahead

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