Podcasts

Yoko Li, Guido Appenzeller, and Joel de la Garza discuss OpenClaw, the open source personal AI assistant that's forcing a rethink of how identity, permissions, and security work on the internet. They cover why setting up Gmail integration took seven hours, what happens when an agent asks for domain-wide access to every email in your company, and why consumer websites like DoorDash and Amazon have no incentive to make their services agent-friendly. Resources: Follow Yoko Li on X: https://twitter.com/stuffyokodraws Follow Guido Appenzeller on X: https://twitter.com/appenz Follow Joel de la Garza on LinkedIn: https://www.linkedin.com/in/3448827723723234/ Check out everything a16z is doing with artificial intelligence here, including articles, projects, and more podcasts. Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investo

Erik Torenberg sits down with Jacob Helberg to discuss AI, manufacturing, supply chains, and the new geopolitics of technology. Drawing on themes from Helberg’s book The Wires of War, they explore why hardware, industrial capacity, and secure supply chains have become central to both economic strength and national security. They also unpack what it means to “win the AI race” — from model leadership and global adoption to energy, compute, tariffs, and reindustrialization in the U.S. Resources: Find Jacob Helberg on X: https://x.com/jacobhelberg Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential inve

Vishal Misra returns to explain his latest research on how LLMs actually work under the hood. He walks through experiments showing that transformers update their predictions in a precise, mathematically predictable way as they process new information, explains why this still doesn't mean they're conscious, and describes what's actually required for AGI: the ability to keep learning after training and the move from pattern matching to understanding cause and effect. Resources: Follow Vishal Misra on X: https://x.com/vishalmisra https://x.com/martin_casado Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or pot

with Olivia Moore

In this episode, originally aired on Big Technology Podcast, Olivia Moore discusses whether AI startups can compete with the big chatbots, why American sentiment toward AI is so negative, and what she learned from giving LLMs personality tests. She also breaks down where ChatGPT, Claude, and Gemini are diverging, why Open Claw signals a new wave of agentic products, and what makes memory the most underrated feature in consumer AI. Resources: Follow Olivia Moore on X: https://x.com/omooretweets Follow Alex Kantrowitz on X: https://x.com/Kantrowitz List to Big Technology Podcast: https://www.youtube.com/playlist?list=PLADd6sStSis77HKfbf4KCY6SvthfxeUgn Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advi

with David Senra

Marc Andreessen joins David Senra for a conversation about entrepreneurship, history, and what drives some of the world’s most ambitious builders. In this conversation with David, Marc reflects on patterns he’s seen across great founders, why many of them focus relentlessly on building rather than introspection, and how technology and entrepreneurship continue to shape the future. Resources: David Senra Website: https://www.davidsenra.com X: https://x.com/davidsenra Show notes: https://www.davidsenra.com/episode/ma... Marc Andreessen X: https://x.com/pmarca a16z: https://a16z.com/author/marc-andreessen Substack: https://pmarca.substack.com Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be u

A.I. is changing the ways war is waged. This week, we explore how the U.S. and Israel are using A.I. to identify targets in the conflict with Iran — and why data centers and fiber optic cables are targets on the front lines. Then, researcher Julie Bedard breaks down “A.I. brain fry,” a new condition she and her colleagues studied among A.I. users at work. And finally, Casey shares his battle with Grammarly after the company used his identity in a new A.I. feature, without his consent. Guest: Julie Bedard, managing director and partner at Boston Consulting Group who is also the lead author of a survey of “A.I. brain fry” in the workplace. Additional Reading: U.S. at Fault in Strike on School in Iran, Preliminary Inquiry Says How A.I. Is Turbocharging the War in Iran Anthropic’s A.I. tool Claude central to U.S. campaign in Iran, amid a bitter feud A.I. Fatigue Is Real and Nobody Talks About It Token Anxiety A.I. Doesn’t Reduce Work — It Intensifies It Grammarly Is Using Our Identities Wi

This conversation with Emil Michael, undersecretary of defense for research and engineering and acting director of the Defense Innovation Unit, was recorded at the a16z American Dynamism Summit in Washington, D.C. Michael walks through how he inherited a department running 14 undefined technology priorities, cut them to six, and made applied AI number one. He also gives the first detailed account of why commercial AI contracts written under the previous administration created a vendor-lock crisis that put active military operations at risk. Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investo

This conversation with Alex Karp, cofounder and CEO of Palantir, was recorded at the a16z American Dynamism Summit in Washington, D.C. Karp discusses the role of technology in modern warfare, Silicon Valley's obligations to national defense, and why he believes America's single greatest competitive advantage is its ability to cultivate and protect unconventional talent. Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an A

Jeff Kaplan is a legendary Blizzard game designer of World of Warcraft and Overwatch, now preparing to launch a new game, The Legend of California, from his new studio Kintsugiyama – available to wishlist on Steam today, with alpha later in March. https://lexfridman.com/sponsors/ep493-sc CONTACT LEX: Feedback – give feedback to Lex: https://lexfridman.com/survey AMA – submit questions, videos or call-in: https://lexfridman.com/ama Hiring – join our team: https://lexfridman.com/hiring Other – other ways to get in touch: https://lexfridman.com/contact EPISODE LINKS: https://store.steampowered.com/app/2550530/The_Legend_of_California https://www.kintsugiyama.com/ SPONSORS: Fin: AI agent for customer service. https://fin.ai/lex Blitzy: AI agent for large enterprise codebases. https://blitzy.com/lex BetterHelp: Online therapy and counseling. https://betterhelp.com/lex Shopify: Sell stuff online. https://shopify.com/lex CodeRabbit: AI-powered code reviews. https://coderabbit.ai/lex Perplexit

with Flock Safety's CEO

In this episode, previously aired on Cheeky Pint, Garrett Langley describes how a stolen gun in his Atlanta neighborhood led him to build Flock Safety, now deployed in more than 6,000 cities and involved in clearing over a million crimes last year. He covers how the product has evolved from license plate cameras to drones, real-time 911 integration, and an AI-powered orchestration layer for city safety. Resources: Follow Garrett Langley on X: https://twitter.com/glangley Follow John Collison on X: https://twitter.com/collision Listen to Cheeky Pint: https://www.youtube.com/playlist?list=PLcoWp8pBTM3BxiPMHCj0YJ4wvGbUOYZIG Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any

Jack Neel speaks with Amjad Masad, CEO at Replit, about how AI is making it easier than ever to build and ship software without a technical background. They discuss Replit's rise from a browser-based coding tool to a platform generating $250 million in annual revenue, why Masad turned down a $1 billion acquisition offer, and his case for why AI represents empowerment rather than existential risk. This episode originally aired on The Jack Neel Podcast. Resources: Follow Amjad Masad on X: https://twitter.com/amasad Follow Jack Neel on X: https://twitter.com/jackhneel Listen to Jack Neel: https://www.youtube.com/jackneel Check out everything a16z is doing with artificial intelligence here, including articles, projects, and more podcasts. Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a

Anish Acharya speaks with Olivia Moore about the latest edition of the a16z Top 100 AI Apps report. They cover why ChatGPT is still 30 times bigger than Claude on web, how the three major platforms are specializing for different users, what global adoption data reveals about cultural attitudes toward AI, and why agents, memory, and voice are about to change everything. Resources: Follow Anish Acharya on X: https://twitter.com/illscience Follow Olivia Moore on X: https://twitter.com/omooretweets Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates ma

Daisy Wolf speaks with Dr. Andrew Huberman, professor of neurobiology and ophthalmology at Stanford University and host of the Huberman Lab podcast. They discuss how the pandemic sparked a consumer health revolution, the emerging peptide and GLP landscape, what the science actually says about focus drugs, and the neurotechnologies Huberman believes will let us write to our own biology within the next five years. Resources: Follow Andrew Huberman on X: https://twitter.com/hubermanlab Follow Daisy Wolf on X: https://twitter.com/daisydwolf Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors i

Alex Rampell and Erik Torenberg speak with Mike Cannon-Brookes, cofounder and CEO of Atlassian, about how to make sense of the SaaS selloff, why not all software companies face the same AI-driven risks, and how Atlassian is thinking about the shift from records to processes. They also examine the real design challenge of getting everyday users to trust and benefit from AI agents in enterprise workflows. Resources: Follow Alex Rampell on X: https://twitter.com/arampell Follow Erik Torenberg on X: https://twitter.com/eriktorenberg Follow Mike Cannon-Brookes on X: https://twitter.com/mcannonbrookes Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; a

This week, the fallout continues as OpenAI scrambles to rework its deal with the Pentagon, while government agencies adapt to life without Claude. Then we break down the grim new reality of prediction market bets on the U.S.-Israel led war with Iran. Finally, it’s time for another edition of The Hard Fork Review of Slop. This time we’re joined by Arijeta Lajka, a New York Times reporter, to discuss her recent article about the short form A.I.-generated slop YouTube is feeding to young children. Guest: Arijeta Lajka, New York Times video journalist Additional Reading: The Pentagon Officially Notifies Anthropic That It Is a ‘Supply Chain Risk’ OpenAI Amends A.I. Deal With the Pentagon How Talks Between Anthropic and the Defense Dept. Fell Apart How Anonymous Bettors Cashed In on the Iran Strike, Just Hours Before It Happened Israeli Army Reservists Are Suspected of Using Inside Knowledge to Bet How A.I.-Generated Videos Are Distorting Your Child’s YouTube Feed We want to hear from you. E

In this conversation, previously aired on TBPN, John Coogan and Jordi Hays speak with Ben Thompson, founder of Stratechery, about his essay "Anthropic and Alignment" and the broader collision between AI power and state power that the Anthropic–Department of War standoff revealed. Resources: Follow Ben Thompson on X: https://twitter.com/benthompson Follow John Coogan on X: https://twitter.com/johncoogan Follow Jordi Hays on X: https://twitter.com/jordihays Follow TBPN on X: https://twitter.com/tbpn Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates

a16z general partner Julie Yoo talks with Nikhil Buduma, CEO and cofounder of Ambience Healthcare, to discuss how AI is transforming clinical workflows. They cover the early days of deep learning, why Ambience started by running a medical practice before building a platform company, and what it takes to achieve high clinician adoption rates at major academic medical centers. They also dig into the challenge of building products when AI capabilities change every few months, the real ROI that's finally converting CFOs, and why this might be the moment to reimagine the legacy EHR stack. Resources: Follow Nikhil Buduma on X: https://twitter.com/nkbuduma Follow Julie Yoo on X: https://twitter.com/julesyoo If you enjoyed this episode, be sure to like, subscribe, and share with your friends! Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktoren

Jack Altman sits down with Martin Casado, General Partner at a16z, to unpack the shifting dynamics of venture capital and why media matters more than ever. They cover a16z’s evolution from generalists to specialized platforms, the rise of AI infrastructure, and why today’s fiercest battles are often for talent, not market share. Timecodes: 0:00 Introduction 0:27 Importance of Media for VC 3:50 Evolution of a16z 7:00 Specialization 10:32 Value of Distribution 13:16 Staying Power in Infrastructure 19:49 The Conflicts Dynamic 26:32 State of Play in AI 30:48 The Future of Coding 34:58 Significance of Open Source 39:48 Marc Andreessen’s Leadership 44:02 The Only Sin in VC 48:37 Scaling a Lot of Board Seats Resources: Listen to more from Uncapped: https://linktr.ee/uncappedpod Find Jack on X: https://x.com/jaltma Find Uncapped on X: https://x.com/uncapped_pod Find Martin on X: https://x.com/martin_casado Stay Updated: Let us know what you think: https://ratethispodcast.com/a16z Find a16z on

On the show Long Strange Trip, Sequoia Capital partner Brian Halligan speaks with a16z’s Ben Horowitz about what separates great founder CEOs from everyone else. Ben explains why first-time founders lose confidence, defer too much to senior hires, and let decision debt paralyze their companies. They discuss where founder mode works and where people are taking it too far, why the VP of Sales is the hire founders mess up more than any other, and why Andy Grove's "constructive confrontation" matters more than most CEOs realize. Ben also shares what he's learned working with Zuckerberg, what Jensen Huang and Elon Musk actually have in common, and why culture is defined by behavior, not values. Resources: Follow Brian Halligan on X: https://twitter.com/bhalligan Follow Ben Horowitz on X: https://twitter.com/bhorowitz Listen to more from Long Strange Trip: https://www.youtube.com/playlist?list=PLOhHNjZItNnNu8wknSuVtcSJRs7Q4xqOE Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find

In this feed drop from the Internet History Podcast, host Brian McCullough speaks with Chris Dixon, general partner at a16z, about his path from 1980s hobbyist programmer to one of the most prominent venture capitalists in tech. Chris traces his career from quantitative finance to founding SiteAdvisor, cofounding Founder Collective, starting an early machine learning company, and eventually building a16z's crypto practice from the ground up. They also discuss his framework for spotting unconventional investments, the current state of crypto regulation, and why New York is becoming a serious tech hub. Resources: Follow Chris Dixon on X: https://twitter.com/cdixon Follow Brian McCullough on X: https://twitter.com/brianmcc Listen to Internet History Podcast: https://www.youtube.com/@internethistorypodcast Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twi