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Podcasts

Lexicon、Lex Fridman、Hard Fork、a16z Podcast、AI + a16zから厳選したエピソードをお届けします。世界トップクラスのエンジニア、科学者、イノベーターとの深い対話をお楽しみください。

Martin Shkreli on AI, Pharma, and What Actually Matters

a16z Podcast·Ep. 1087· 2927·Apr 23, 2026

Erik Torenberg speaks with Martin Shkreli, American investor and businessman, about how he sees the AI landscape, from OpenAI to Anthropic, and what actually matters beyond the hype. They also talk through the future of computing, the limits of “vibe coding,” and why biotech and pharma remain some of the toughest industries to get right. Resources: Follow Martin on X: https://x.com/MartinShkreli Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Balaji Srinivasan: Prove Correct, Not Just Go Direct

a16z Podcast·Ep. 1085· 7293·Apr 22, 2026

Erik Torenberg and Theo Jaffee speak with Balaji Srinivasan, angel investor, entrepreneur, and author of The Network State, about how AI is transforming media, eroding trust, and reshaping how information is created and verified. They discuss why systems like hiring, journalism, and online communication are breaking under synthetic content, and what replaces them. The conversation also examines the role of cryptography, on-chain data, and new models of proof in rebuilding trust online. Resources: Follow Balaji on X: https://x.com/balajis Follow Erik Torenberg on X: https://twitter.com/eriktorenberg Follow Theo Jaffee on X: https://x.com/theojaffee Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice

a16z Podcast·Ep. 1084· 4038·Apr 21, 2026

Erik Torenberg and Theo Jaffee speak with Marc Andreessen, cofounder and general partner at a16z, about the launch of Monitoring the Situation (MTS), a new, always-on media network on X. They discuss the rise of the “current thing,” how narratives spread in real time, and why internet-native media is reshaping politics, culture, and attention. Resources: Follow Marc X: https://x.com/pmarca Follow Eric on X: https://x.com/eriktorenberg Follow Theo on X: https://x.com/theojaffee Follow MTS on X: https://x.com/MTSlive Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z

with Anish Acharya on The Kevin Rose Show

a16z Podcast·Ep. 1082· 3525·Apr 19, 2026

This episode originally aired on The Kevin Rose Show. Kevin Rose speaks with Anish Acharya, general partner at a16z, about how AI is rewriting the rules of consumer software, the defensibility of network effects in a world where anyone can spin up an app in 48 hours, and why the real threat to consumer founders may be the cost of inference, not competition. They also discuss model pricing, the future of the four-day work week, and peptides. Resources: Follow Anish on X: https://x.com/illscience Follow Kevin on X: https://x.com/kevinrose Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors i

Hard Fork·Ep. 190· 3801·Apr 17, 2026

This week, amid violent attacks on the homes of the OpenAI chief executive Sam Altman and the Indianapolis councilman Ron Gibson, we debate why artificial intelligence and data centers are so unpopular. Then, Kara Swisher returns to the show to discuss her new docuseries on Silicon Valley’s obsession with living longer. And finally, can chief executives replace themselves with A.I.? Mark Zuckerberg seems to be trying. Guests: Kara Swisher, tech journalist and host of the podcasts “Pivot” and “On With Kara Swisher.” Additional Reading: Shots Fired at Indianapolis Councilman’s Home, After Vote Backing Data Center Man Held in Attack on OpenAI Chief’s Home Had List of A.I. Leaders, Officials Say Kara Swisher Wants to Live Forever Meta Builds A.I. Version of Mark Zuckerberg to Interact With Staff We want to hear from you. Email us at [email protected]. Find “Hard Fork” on YouTube and TikTok. Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe

with Dmitri Dolgov

a16z Podcast·Ep. 1081· 3841·Apr 17, 2026

Waymo is now delivering hundreds of thousands of fully autonomous rides each week — but getting there required more than better models. It meant building a complete system for training, evaluating, and deploying a driver in the real world. In this episode — originally aired on the Cheeky Pint podcast — Waymo Co-CEO Dmitri Dolgov joins John Collison to break down how self-driving actually works today: from sensor fusion across LiDAR, radar, and cameras, to simulation, “critic” models, and the role of AI in decision-making. They also explore why full autonomy is fundamentally different from driver-assist, what it takes to scale globally, and how recent advances in AI are reshaping the path forward. Resources: Follow Dmitri Dolgov on X - https://x.com/dmitri_dolgov Follow John Collison on X - https://x.com/collision Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host:

a16z Podcast·Ep. 1081· 3841·Apr 17, 2026

Waymo is now delivering hundreds of thousands of fully autonomous rides each week — but getting there required more than better models. It meant building a complete system for training, evaluating, and deploying a driver in the real world. In this episode — originally aired on the Cheeky Pint podcast — Waymo Co-CEO Dmitri Dolgov joins John Collison to break down how self-driving actually works today: from sensor fusion across LiDAR, radar, and cameras, to simulation, “critic” models, and the role of AI in decision-making. They also explore why full autonomy is fundamentally different from driver-assist, what it takes to scale globally, and how recent advances in AI are reshaping the path forward. Resources: Follow Dmitri Dolgov on X - https://x.com/dmitri_dolgov Follow John Collison on X - https://x.com/collision Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host:

with signüll

a16z Podcast·Ep. 1080· 2052·Apr 16, 2026

Erik Torenberg and Anish Acharya, general partners at a16z, speak with signüll about how technology reshapes culture, relationships, and the products we build. The conversation covers tacit knowledge versus intellectual knowledge, dating apps and their effect on human connection, AI relationships, why Claude feels artisan while other models feel utilitarian, and what consumer founders should actually care about. Resources: Follow signüll on X: https://twitter.com/signulll Follow Anish Acharya on X: https://twitter.com/illscience Follow Erik Torenberg on X: https://twitter.com/eriktorenberg Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is

a16z Podcast·Ep. 1079· 1783·Apr 14, 2026

Recorded live at the a16z Fintech Connect conference in Deer Valley, Alex Rampell speaks with Ben Horowitz, cofounder and general partner at a16z, about how AI has rewritten the fundamental rules of software competition, why crypto infrastructure will become essential in an AI-dominated world, and what the future holds for venture capital. Resources: Follow Alex Rampell on X: https://twitter.com/arampell Follow Ben Horowitz on X: https://twitter.com/bhorowitz Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the compan

a16z Podcast·Ep. 1078· 3279·Apr 13, 2026

Katherine Boyle and Sarah Wang speak with Jesse Genet, a self-proclaimed startup founder and family builder, about building 11 AI agents while homeschooling four young children. Jesse runs agents across roles ranging from coding to curriculum planning to household management, and she shares how agent architecture, logging systems, and “benevolent neglect” parenting have changed her life as both a founder and a mother. Resources: Follow Jesse Genet on X: https://twitter.com/jessegenet Follow Katherine Boyle on X: https://twitter.com/KTmBoyle Follow Sarah Wang on X: https://twitter.com/sarahdingwang Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security;

Hard Fork·Ep. 189· 3846·Apr 10, 2026

This week, we look at the cybersecurity threats that a new unreleased model from Anthropic are posing to software everywhere. And we ask whether Project Glasswing, the company’s bold new defense initiative, will give tech companies enough of a head start to secure the web. Then, we’re joined by Ronan Farrow and Andrew Marantz of The New Yorker to discuss their blockbuster new profile of Sam Altman. And finally, we look to the skies for this edition of One Good Thing. Guests: Ronan Farrow, investigative reporter and a contributing writer to The New Yorker. Andrew Marantz, staff writer at The New Yorker. Additional Reading: Anthropic Claims Its New A.I. Model, Mythos, Is a Cybersecurity ‘Reckoning’ Why Anthropic’s New Model Has Cybersecurity Experts Rattled Sam Altman May Control Our Future — Can He Be Trusted? Artemis II Moon Launch We want to hear from you. Email us at [email protected]. Find “Hard Fork” on YouTube and TikTok. Subscribe today at nytimes.com/podcasts or on Apple Podc

with Taught Steven Sinofsky About Apple

a16z Podcast·Ep. 1077· 1883·Apr 10, 2026

Theo Jaffee speaks with Steven Sinofsky, board partner at a16z and former president of the Windows division at Microsoft, about Apple's 50th anniversary, the cultural differences that separated Apple and Microsoft, why the MacBook Neo puts Windows laptops in a difficult position, and what the history of computing design reveals about where hardware and software are headed. Resources: Follow Steven Sinofsky on X: https://twitter.com/stevesi Follow Theo Jaffee on X: https://twitter.com/theojaffee Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates ma

Lex Fridman Podcast·Ep. 20· 7796·Apr 9, 2026

Lars Brownworth is a historian, teacher, podcaster, and author specializing in Viking history, medieval Europe, and the Byzantine Empire. https://lexfridman.com/sponsors/ep495-sc Transcript: https://lexfridman.com/lars-brownworth-transcript CONTACT LEX: Feedback – give feedback to Lex: https://lexfridman.com/survey AMA – submit questions, videos or call-in: https://lexfridman.com/ama Hiring – join our team: https://lexfridman.com/hiring Other – other ways to get in touch: https://lexfridman.com/contact EPISODE LINKS: https://larsbrownworth.com/ https://www.amazon.com/Sea-Wolves-History-Vikings/dp/1909979120 https://amzn.to/4sHY0xw https://12byzantinerulers.com/ https://apple.co/4sgSxNi SPONSORS: Larridin: Measure AI adoption in your business. https://larridin.com BetterHelp: Online therapy and counseling. https://betterhelp.com/lex LMNT: Zero-sugar electrolyte drink mix. https://drinkLMNT.com/lex Fin: AI agent for customer service. https://fin.ai/lex Shopify: Sell stuff online. https:/

a16z Podcast·Ep. 1076· 5940·Apr 9, 2026

Eddy Lazzarin speaks with Vitalik Buterin, founder of Ethereum, and Guillaume Verdon, founder and CEO of Extropic, about whether AI progress can or should be steered, the risks of concentrated power, and what open source and decentralization mean for who benefits from increasingly powerful systems. This episode originally aired on the a16z crypto podcast. Resources: Follow Vitalik Buterin on X: https://twitter.com/VitalikButerin Follow Guillaume Verdon on X: https://twitter.com/GillVerd Follow Eddy Lazzarin on X: https://twitter.com/eddylazzarin Follow Shaw Walters on X: https://twitter.com/shawmakesmagic Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or s

with GitHub Cofounder Scott Chacon

AI + a16z·Ep. 93· 2825·Apr 8, 2026

Matt Bornstein speaks with Scott Chacon, cofounder of GitHub and CEO of GitButler, about why Git's user interface has barely changed since 2005, how GitButler is rethinking version control for both humans and AI agents, and what the "next GitHub" might actually look like. They cover parallel branches, agent-optimized CLI design, the future of code review, and why the best engineers of the future will be the best writers. Resources: Follow Scott Chacon on X: https://twitter.com/chacon Follow Matt Bornstein on X: https://twitter.com/BornsteinMatt Check out everything a16z is doing with artificial intelligence here, including articles, projects, and more podcasts. Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies

with Box CEO Aaron Levie

a16z Podcast·Ep. 1074· 3577·Apr 8, 2026

Erik Torenberg, Steve Sinofsky, and Martin Casado speak to Aaron Levie, CEO at Box, about what happens to enterprise software when agents become the primary users. They discuss why coding agents succeed where other knowledge work agents struggle, what abstraction layers mean for the workforce, and how data access and systems of record must change in an agent-first world. Resources: Follow Aaron Levie on X: https://twitter.com/levie Follow Steve Sinofsky on X: https://twitter.com/stevesi Follow Martin Casado on X: https://twitter.com/martin_casado Follow Erik Torenberg on X: https://twitter.com/eriktorenberg Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or

a16z Podcast·Ep. 1073· 4027·Apr 7, 2026

a16z general partner Erik Torenberg speaks with Balaji Srinivasan, angel investor and entrepreneur, about why AI simultaneously reduces the cost of creation and increases the cost of verification, and what that tension means for the shape of the AI economy. They discuss why AI drives companies toward the "trusted tribe" model of the Chinese internet, why physical world tasks are easier to automate than digital ones, why shortcuts only work for experts, and why AI makes everyone a CEO rather than making CEOs obsolete. Resources: Follow Balaji Srinivasan on X: https://twitter.com/balajis Follow Erik Torenberg on X: https://twitter.com/eriktorenberg Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice

a16z Podcast·Ep. 1072· 1717·Apr 6, 2026

Anish Acharya speaks with Peter Yang, creator and product lead at Roblox, about how personal AI agents are replacing the apps we open every day, why coding agents feel like slot machines, and what happens when the cost of building software drops to near zero. They discuss why future companies will stay radically small, how the IDE is becoming a thinking tool rather than a making tool, and why human ambition will always create more jobs than AI eliminates. Follow Peter Yang on X: https://x.com/petergyang Follow Anish Acharya on X: https://x.com/illscience Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or pot

a16z Podcast·Ep. 1071· 4648·Apr 3, 2026

This episode originally aired on the Latent Space Podcast. swyx and Alessio Fanelli speak with Marc Andreessen about the arc of AI from its origins in 1943 to today's breakthroughs in reasoning, coding agents, and self-improvement. They cover the parallels between AI scaling laws and Moore's Law, the architectural insight behind Claude Code and the Unix shell, the coming supply crunch in compute, and why the messy reality of 8 billion people means both AI utopians and doomers are too optimistic about the pace of change. Follow Marc Andreessen on X: https://twitter.com/pmarca Follow Shawn "swyx" Wang on X: https://twitter.com/swyx Follow Alessio Fanelli on X: https://twitter.com/FanaHOVA Listen to Latent Space. Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; s

Hard Fork·Ep. 188· 4166·Apr 3, 2026

Last week, two separate juries held social media companies liable for harming young users. We unpack what these landmark decisions mean — not only for the future of social platforms like Meta and YouTube, but also for A.I. chatbots. Then, Sebastian Mallaby, the author of “The Infinity Machine,” joins us to talk about the three years he spent with Demis Hassabis and those closest to Google DeepMind. And finally, we catch up on some of our favorite tech headlines from the week with a round of HatGPT. Guest: Sebastian Mallaby, author of “The Infinity Machine: Demis Hassabis, DeepMind and the Quest for Superintelligence.” Additional Reading: Juries Take the Lead in the Push for Child Online Safety An A.I. Agent Was Banned From Creating Wikipedia Articles, Then Wrote Angry Blogs About Being Banned I Met Olaf — the Frozen Robot who Might be the Future of Disney Parks Claude’s Code: Anthropic Leaks Source Code for A.I. Software Engineering Tool What’s With All the A.I. Videos of Cheating Frui

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Marc Andreessen: Monitoring the Situation and the Future of Media

Network Effects, AI Costs, and the Future of Consumer Investing with Anish Acharya on The Kevin Rose Show

A.I. Backlash Turns Violent + Kara Swisher on Healthmaxxing + The Zuck Bot Is Coming

From Models to Mobility: Building Waymo with Dmitri Dolgov

The System Behind Self-Driving: Waymo’s Dmitri Dolgov

Technology, Culture, and the Next AI Interface with signüll

Ben Horowitz on AI Infrastructure, Economics and The New Laws of Software

Building Agents at Home: Parenting, Work, and Benevolent Neglect

Anthropic’s Cybersecurity Shock Wave + Ronan Farrow and Andrew Marantz on Their Sam Altman Investigation + One Good Thing

What Running Windows at Microsoft Taught Steven Sinofsky About Apple

#495 – Vikings, Ragnar, Berserkers, Valhalla & the Warriors of the Viking Age

Who Controls AI Acceleration? Vitalik Buterin and Guillaume Verdon Debate

Rethinking Git for the Age of Coding Agents with GitHub Cofounder Scott Chacon

The Agent Era: Building Software Beyond Chat with Box CEO Aaron Levie

Balaji on Why AI Raises the Cost of Verification

Peter Yang on Small Teams, Coding Agents, and Why Human Ambition Has No Ceiling

Marc Andreessen on AI Winters and Agent Breakthroughs

The Future of Addictive Design + Going Deep at DeepMind + HatGPT