#hippocampus

All articles tagged with "hippocampus"

Study constructs the largest multiomic atlas of the adult human hippocampus from nonmedicated MDD individuals and controls.
Identifies a neurogenic lineage in the subgranular zone and shows evidence of a stalled neurogenic process in MDD.
Stalling is associated with transcriptional regulation, stress-related reprogramming, and interferon signaling across developmental stages.
Excitatory and inhibitory neurons show dysregulated transcription factor networks affecting cell states.

DT Editorial Team·Aug 23, 2026·via nature.com

Researchers analyzed nearly 500,000 hippocampal cells from depressed and non-depressed individuals.
Neurogenesis, the production of new neurons, stalls in the brains of adults with major depressive disorder.
The study identifies molecular programs controlling neurogenesis as potential therapeutic targets.
Depression is framed not just as serotonin deficiency but as a failure of neural plasticity.

DT Editorial Team·Aug 21, 2026·via medicalxpress.com

Researchers linked estrogen loss to changes in the brain’s extracellular matrix.
The hippocampus appeared especially affected in older female mice.
The work could help explain why women face higher Alzheimer’s risk.

DT Editorial Team·May 27, 2026·via refractor.io

Researchers are highlighting behavioral timescale synaptic plasticity, or BTSP, as a new learning mechanism.
BTSP may help explain how the brain learns from experiences unfolding over several seconds.
The theory focuses on hippocampal circuits and rapid memory formation after a single event.

DT Editorial Team·Apr 27, 2026·via quantamagazine.org