#CAR T therapy

All articles tagged with "CAR T therapy"

A Nature Medicine study published online 23 September 2026 examines enterocolitis in multiple myeloma patients treated with BCMA-directed CAR-T therapy.
The paper's title highlights two linked findings: persistence of mucosal CAR-T cells and inflammatory remodeling in the gut.
The work is described as a multimodal analysis, drawing on multiple lines of evidence rather than a single assay or time point.
Enterocolitis is difficult to diagnose because infections, medications, and immune-driven inflammation can produce overlapping symptoms.

DT Editorial Team·Sep 25, 2026·via nature.com

Rutgers researchers linked CAR T underperformance to senescent CD8+ T cells used as starting material.
Higher senescence burdens reduced cell expansion under standard CAR T culture conditions.
Analysis of published lymphoma data found stronger senescence signatures were associated with higher failure risk.
The work suggests pre-manufacturing cell-quality screening could improve patient selection and product design.

DT Editorial Team·Apr 30, 2026·via medicalxpress.com