#blood stem cells

All articles tagged with "blood stem cells"

Activated protein C and thrombin act through the same PAR1 receptor but produced different outcomes in human blood stem cells.
aPC-treated cells remained more quiescent and were less likely to differentiate prematurely.
A one-hour aPC treatment improved transplantability in a mouse model, but clinical usefulness remains unproven.

DT Editorial Team·Oct 9, 2026·via medicalxpress.com

ChromAgeNet is an AI-based tool that detects aging-associated patterns in microscopy images of hematopoietic stem cells by analyzing the three-dimensional organization of chromatin.
The study was led by Dr. Maria Carolina Florian of IDIBELL and Dr. Paula Petrone of BSC-CNS and ISGlobal, and formed a central part of Pablo Iañez's doctoral thesis.
Training used 3D images of mouse hematopoietic stem cell nuclei stained with DAPI, with a convolutional neural network learning to distinguish young from aged cells.
The model had a 77% probability of correctly classifying cells as young or aged, outperforming a machine learning model based on previously defined chromatin features.

DT Editorial Team·Sep 28, 2026·via medicalxpress.com