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De Novo Mutations Link Parental Reproductive Factors to Offspring Health
Key Takeaways
- The study appears in Nature Medicine, published online 14 September 2026.
- Whole-genome sequencing covered 7,851 parent–offspring families.
- The analysis identified parent-of-origin effects and a second, post-zygotic class of mutation signatures.
- De novo mutations are newly arising changes not inherited from either parent, making family-based sequencing essential to detect them.
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DT Editorial Team··via nature.com