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A Multimodal Murmuration: Combining Biomarkers to Predict Immunotherapy Response
Key Takeaways
- A Nature Medicine article published 13 September 2026 reports that integrating numerous multimodal, patient-level biomarkers enhances prediction of cancer immunotherapy response.
- No single biomarker reliably captures whether a patient will respond, because response depends on layered biology spanning tumor genomics, the immune microenvironment and host tolerance.
- Combining genomic, transcriptomic, proteomic, imaging and clinical data can suppress noise, tolerate missing measurements and support better trial enrichment.
- Barriers to clinical adoption include cross-site validation, assay standardization, cost and the interpretability of complex integrative models.
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DT Editorial Team··via nature.com