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Stalled Neurogenesis in Major Depression: Largest Human Hippocampus Atlas Reveals New Targets
Key Takeaways
- Study constructs the largest multiomic atlas of the adult human hippocampus from nonmedicated MDD individuals and controls.
- Identifies a neurogenic lineage in the subgranular zone and shows evidence of a stalled neurogenic process in MDD.
- Stalling is associated with transcriptional regulation, stress-related reprogramming, and interferon signaling across developmental stages.
- Excitatory and inhibitory neurons show dysregulated transcription factor networks affecting cell states.
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DT Editorial Team··via nature.com