#ketamine

All articles tagged with "ketamine"

Existing drug combinations show new promise for treatment-resistant depression

Two new JAMA Psychiatry analyses suggest existing medicines may help patients whose depression has not improved after standard treatment, with intravenous ketamine showing rapid short-term effects and combination therapy

Key Takeaways

Researchers reviewed 26 randomized controlled trials of intravenous ketamine.
Ketamine outperformed placebo over the short term and appeared comparable to esketamine.

DT Editorial Team·May 10, 2026·via medicalxpress.com

Researchers Trace Ketamine’s Fast Antidepressant Effects to a Specific Brain Circuit

A new Cell study identifies a specific subset of opioid receptors on prefrontal cortex interneurons as a key part of ketamine’s rapid antidepressant action, opening the door to more targeted therapies.

Key Takeaways

Researchers published the study in Cell.
The work links ketamine’s effects to specific opioid receptors on prefrontal cortex interneurons.

DT Editorial Team·May 1, 2026·via medicalxpress.com

Researchers test a new approach to severe stimulant-related agitation

A preclinical study from Marshall University suggests a dexmedetomidine-ketamine combination may control methamphetamine-induced agitation with deeper early sedation and fewer side effects than high-dose dexmedetomidine,

Key Takeaways

A Marshall University preclinical study tested a dexmedetomidine-ketamine approach for methamphetamine-induced agitation.
The combination nearly completely controlled agitation in rats and showed less intense side effects than high-dose dexmedetomidine.

DT Editorial Team·Apr 27, 2026·via medicalxpress.com