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Chronic Type II Interferon Can Fuel Tumor Growth, Study Finds
Key Takeaways
- A study in Science (Vol. 393, Issue 6816, pp. 1107–1116) reports that chronic type II interferon signaling can promote tumor growth rather than suppress it.
- The proposed pathway runs through mitochondrial RNA–induced type I interferon and prostaglandin synthesis.
- The findings highlight the acute-versus-chronic distinction in interferon biology and its consequences for antitumor immunity.
- Implications touch on immunotherapy dosing, mitochondrial RNA handling, prostaglandin pathways, and how interferon signatures are interpreted as biomarkers.
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DT Editorial Team··via science.org