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Aging brains may decline in part because myelin-making cells go wrong
Key Takeaways
- Researchers linked worse cognitive aging trajectories to white matter changes involving oligodendrocytes.
- The human data associated poorer outcomes with smaller myelinated axons, thicker myelin and lower NRF2 activity.
- Aged mice lacking NRF2 in oligodendrocytes showed matching pathology and weaker cognitive improvement.
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DT Editorial Team··via nature.com