Health
Estrogen-Driven IL-33 Pathway Explains Why Asthma Hits Women Harder
Imperial College London researchers uncover how estrogen amplifies allergic lung inflammation through IL-33 and EGFR signaling in female airways.
Key Takeaways
- Imperial College London identifies how estrogen increases IL-33 production in lung fibroblasts, worsening asthma in women
- Elevated IL-33 boosts EGFR expression on TH2 immune cells, amplifying the type 2 inflammatory cascade in airways
- The finding explains why asthma severity flips after puberty, hitting women harder during pregnancy and menopause
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