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Microglia at Key Inflection Point in Alzheimer’s Disease Revealed by Spatial Transcriptomics
Key Takeaways
- Spatial transcriptomics of brains from octogenarians and resilient centenarians identified microglia gene expression changes at the amyloid-tau boundary.
- Six tissue domains were mapped, revealing a critical inflection point where microglia shift from protective to damaging states.
- Cognitively resilient centenarians showed distinct microglial patterns that may protect against dementia despite high pathology.
- Findings could lead to early detection biomarkers and microglia-targeted therapies for Alzheimer's disease.
DE
DT Editorial Team··via nature.com