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ATRX Mutation Rewires Brain Cancer DNA, Revealing New Therapeutic Target
Key Takeaways
- ATRX mutations reprogram the epigenome and change 3D chromatin structure in glioma.
- New DNA interactions activate developmental programs like HOXA genes that fuel tumor growth.
- Targeting HOXA genes in preclinical models slowed cancer progression.
- Study published in Nucleic Acids Research by MD Anderson team.
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DT Editorial Team··via medicalxpress.com