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Biography of an Inherited Lung Cancer Risk Gene: EGFR T790M
Key Takeaways
- A Nature Medicine research highlight, published 28 September 2026, summarizes a study using data from more than 3 million people.
- The work traces the ancestral history of the EGFR T790M germline mutation and its present contribution to lung cancer risk in people who never smoked.
- Rare germline EGFR variants have long been implicated in familial lung cancer, but earlier studies were too small and lacked statistical power.
- Growing concern about lung cancer among never-smokers, as smoking-related cancers decline in many regions, gives the research added relevance.
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DT Editorial Team··via nature.com