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Age-Based Genetic Testing May Miss Most Inherited Cancer Variants
Key Takeaways
- Researchers tested all 39,184 patients with solid tumors at Memorial Sloan Kettering Cancer Center regardless of age, using the MSK-IMPACT assay for 94 germline pathogenic variants.
- 16.3% of patients carried at least one of the tested germline pathogenic variants.
- Limiting testing to patients under 50, the usual cutoff, would have missed the majority of inherited variants found in the cohort.
- Detected variants can flag cancer risk in family members and can potentially guide treatment decisions.
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DT Editorial Team··via medicalxpress.com