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Ceramide Synthesis Tied to Colorectal Cancer Spread via YAP Regenerative Program
Key Takeaways
- A study in Science (Volume 393, Issue 6818) reports that ceramide synthesis mediates colorectal cancer metastasis.
- The mechanism is described as operating through a YAP-driven regenerative program rather than through general tumour growth effects.
- The finding links sphingolipid metabolism with the Hippo/YAP transcriptional pathway that governs tissue regeneration.
- Full experimental details — including specific enzymes, models and causal rescue experiments — are not captured in the available summary.
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DT Editorial Team··via science.org