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Redesigned Nanoparticles Sharpen mRNA Vaccine Delivery
Key Takeaways
- Penn Engineers redesigned ionizable lipids in mRNA vaccine nanoparticles for 4x better lymph node targeting
- Liver off-target delivery reduced by 60%, improving both efficacy and safety potential
- Advance could benefit cancer vaccines and therapeutic mRNA delivery beyond infectious disease
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DT Editorial Team··via phys.org