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CRISPR Screen Identifies CRL5 as a Driver of T-Cell Exhaustion
Key Takeaways
- A UCLA CRISPR screen identified CRL5 as a pathway involved in T-cell exhaustion.
- Blocking CRL5 improved persistence and antitumor responses in preclinical models.
- The work may inform future cell therapies for solid tumors but is not yet a clinical treatment.
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DT Editorial Team··via medicalxpress.com