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DNA Origami Rotor Tracks Gene Transcription at Single-Base Resolution
Key Takeaways
- Salk Institute researchers developed ORBIT, a DNA origami-based method to visualize molecular movements.
- ORBIT uses a dye-cycling strategy to extend fluorescence microscopy observation from seconds to hours.
- The technique tracks RNA polymerase rotation during gene transcription with single base-pair resolution.
- This provides new insights into the mechanical aspects of transcription, complementing chemical knowledge.
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DT Editorial Team··via phys.org