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Slow-Release Nerve Block Delivers Weeks of Pain Relief in Early Study
Key Takeaways
- Boston Children's Hospital researchers formulated a slow-release injectable that produced nerve-numbing effects lasting two to three weeks in rats.
- A commercial formulation tested alongside it lasted only about four to eight hours, while most local anesthetics in medicine wear off within eight to 12 hours.
- The team overturned the belief that drugs leak fastest from liposomes made of more fluid lipids, showing hydrophilic drugs are released extremely slowly from them.
- Liposomes with many double bonds formed multi-compartment, onion-like structures that force hydrophilic drugs to cross more lipid barriers before escaping.
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DT Editorial Team··via medicalxpress.com