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Obesity May Erase Breast Cancer's Natural Defense, Study Finds
Key Takeaways
- Huntsman Cancer Institute researchers found that obesity suppresses a biological process that kills potentially cancerous cells, offering a possible explanation for obesity's link to breast cancer.
- Lean breast adipocytes produce far more of the lipid 9S-HODE than obese adipocytes, and the lipid promotes ferroptosis, a form of programmed cell death.
- Senior author Keren Hilgendorf said the field has focused on how obesity promotes cancer but had not considered that it may also remove a natural protection.
- The team tested whether raising 9S-HODE levels in obese preclinical mouse models could restore the tumor-suppressing signal seen in lean tissue.
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DT Editorial Team··via medicalxpress.com