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Why Newborn Neurons Break and Repair DNA as the Brain Takes Shape
Key Takeaways
- Researchers report that migrating newborn neurons in the developing cortex routinely incur double-strand DNA breaks.
- The study links the damage to mechanical stress during migration and to the enzyme Topoisomerase IIβ.
- Most of the observed DNA breaks were repaired within 24 hours through nonhomologous end joining.
- The findings suggest severe DNA damage can be a normal, repairable part of brain development rather than only a sign of pathology.
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DT Editorial Team··via medicalxpress.com