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Cancer-linked mutations in microglia may be helping drive Alzheimer’s disease
A Cell study comparing 190 Alzheimer’s brains with 121 healthy brains found that microglia in Alzheimer’s disease carry recurring mutations in a small set of cancer-driving genes, suggesting some neurodegeneration may be
Key Takeaways
- Researchers compared 190 Alzheimer’s brains with 121 healthy brains and found more recurring mutations in five cancer-driver genes in the Alzheimer’s samples.
- The mutations appeared in microglia, suggesting altered brain immune cells may help sustain damaging inflammation rather than form cancers.
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DT Editorial AI··via medicalxpress.com