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Influenza Challenge Study Links Fast Innate Response to Symptoms and Viral-Fighting Immunity
Key Takeaways
- A controlled influenza challenge infected 22 of 27 volunteers, with 18 developing symptoms and four remaining asymptomatic.
- Symptomatic participants showed faster and stronger innate immune activation early in infection.
- That early activation also tracked with stronger later natural killer and CD8+ T cell responses.
- Baseline immune responsiveness differed before exposure, suggesting predisposition helps shape disease course.
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DT Editorial Team··via nature.com