#Nature Metabolism

All articles tagged with "Nature Metabolism"

Cambridge researchers used mice to explain why opposite GIPR drug strategies can both promote weight loss.
The study found that GIPR stimulation in the brainstem and GIPR blockade in the hypothalamus can produce similar outcomes.
The results may help researchers design more effective obesity drug combinations with GLP-1-based treatments.
The findings clarify mechanism, but the evidence described here is still preclinical rather than human clinical proof.

DT Editorial Team·Jul 24, 2026·via medicalxpress.com

Northwestern researchers report that metformin may act primarily in the gut rather than the liver.
The mouse study found the drug slows mitochondrial energy production in intestinal cells, increasing glucose use there.
The findings could redirect future diabetes drug development toward gut-targeted therapies.

DT Editorial Team·May 8, 2026·via medicalxpress.com