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PIEZO1 Mechanosensing in Liver Zones Controls Regeneration
Key Takeaways
- PIEZO1 is a mechanosensitive ion channel that regulates liver regeneration.
- Expression of PIEZO1 varies across liver lobule zones, with enrichment in pericentral and periportal regions.
- Mechanical cues such as tissue stiffness and shear stress activate PIEZO1 during regeneration.
- Deletion of PIEZO1 impairs liver regeneration, while overexpression enhances it.
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DT Editorial Team··via science.org