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Ancient Protein Revival Maps How Bacterial Enzymes Evolved Distinct Roles
Key Takeaways
- Researchers reconstructed a long-extinct ancestor of two bacterial nucleases, NrnC and diDNase.
- Initial targeted mutation experiments failed, prompting the team to use ancestral sequence reconstruction.
- The revived protein was produced in the lab and its 3D structure analyzed.
- The work, published in Science Advances, illustrates how related proteins can evolve distinct functions.
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DT Editorial Team··via phys.org