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Dietary Switch Drives Sensory Neuron-Dependent Cancer Cachexia, Study Reveals
Key Takeaways
- Sensory neurons become hyperactive in cancer cachexia and promote muscle wasting.
- A metabolic switch from glucose to fatty acid oxidation in these neurons drives cachexia.
- CPT1a enzyme controls the switch; inhibiting it prevents cachexia in mice.
- CGRP released from sensory neurons causes muscle breakdown.
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DT Editorial Team··via science.org