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Alzheimer's Risk Shaped by Both Brain Pathology and Cognitive Resilience, 15-Year Study Finds
Key Takeaways
- A 15-year cohort study published in Nature Medicine concludes that Alzheimer's dementia risk is jointly shaped by Alzheimer's pathology and cognitive resilience.
- The finding argues against treating brain pathology as a sole determinant of whether someone develops dementia.
- Pathological burden refers to the accumulation and distribution of amyloid plaques and tau tangles in the brain.
- Cognitive resilience describes the brain's ability to maintain function despite damage, a concept related to but distinct from cognitive reserve.
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DT Editorial Team··via nature.com