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Mitochondrial DNA Copy Number Tied to Tumor Growth and Chemotherapy Gene Activity
Key Takeaways
- New research in The FEBS Journal found a correlation between mtDNA copy number and the extent of genetic mutations in cancer cells.
- Increased mtDNA copy number showed a signature of compensation for impaired mitochondrial function in cancer cells.
- Variation in mtDNA copy number was linked to expression of genes associated with chemotherapy response and other aspects of cancer.
- High mtDNA copy number was associated with genes that support tumor growth and survival.
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DT Editorial Team··via medicalxpress.com