Marc Andreessen on AI, Technology, and the Future of Humanity

with Billy Evans? A Spoiler

This week, we focus on Billy Evans, the breakout character of the documentary “You Can See Everything,” and his Theranos-esque new blood-testing start-up. Rob Copeland, a New York Times finance reporter, and Erin Griffith, a tech reporter, join Max Read to discuss what Evans is like when the cameras are off, whether his start-up is a real company and how Silicon Valley is reacting to the film. Then, we break down CoreWeave’s debt, a possible SpaceX-Tesla merger and Joel Kaplan’s Meta exit. Finally, a returning guest: John Carreyrou joins us to answer listener questions about Elizabeth Holmes. Guests: Erin Griffith, a technology reporter at The New York Times Rob Copeland, a finance reporter at The New York Times John Carreyrou, an investigative reporter at The New York Times and author of “Bad Blood” Additional Reading: Elizabeth Holmes’s Partner Has a New Blood-Testing Start-Up The Elizabeth Holmes Documentary, Through the Eyes of the Reporter Who Exposed Her Weak Links Start to Show

Amazon expects to spend roughly $220 billion in CapEx in 2026, yet CEO Andy Jassy says the company is still leaving meaningful AI demand on the table.** He believes the buildout could ultimately help make AWS a $1 trillion annual run-rate business. Andy joins a16z co-founder Ben Horowitz and Erik Torenberg to discuss why AI demand is growing so quickly, how Amazon decides how much infrastructure to build, and why lower inference costs could unlock broader enterprise adoption. They also discuss how AI is reshaping Amazon itself, from smaller teams building products faster to reimagining Alexa, and why Andy sees cybersecurity, human judgment, and critical thinking as increasingly important in the AI era. Resources: Follow Andy Jassy on X: https://x.com/ajassy Follow Ben Horowitz on X: https://x.com/bhorowitz Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https:/

a16z is expanding a16z crypto into a16z Frontier, a broader mandate to back founders building at the edges of what's possible. Chris Dixon joins Marc Andreessen, Ben Horowitz, and Erik Torenberg to explain why founders should increasingly ask not “is this too ambitious?” but “is this ambitious enough?” — and how AI could pull decades of technological progress forward across hardware, robotics, entertainment, science, and entirely new forms of media. They also explore the coming internet of AI agents, why open source matters as AI becomes more powerful, and why some of the most important companies of the next decade may combine technologies and business models that previously belonged in separate categories. Resources: Follow Chris Dixon on X: https://x.com/cdixon Follow Marc Andreessen on X: https://x.com/pmarca Follow Ben Horowitz on X: https://x.com/bhorowitz Learn more about a16z Frontier: https://a16zfrontier.com https://a16zfrontier.substack.com https://x.com/a16zfrontier Stay Upd

AI agents can reason over enormous amounts of information, but much of the world’s actual work is still trapped in PDFs, spreadsheets, scans, and other formats that models struggle to reliably understand. Reducto co-founder and CEO Adit Abraham argues that solving this document layer is essential if agents are going to take on consequential work in healthcare, legal, finance, and insurance. Adit joins a16z General Partner Jennifer Li to explain why traditional OCR breaks down on messy real-world documents, how Reducto combines vision-language models with specialized infrastructure to reach high accuracy without sacrificing cost or latency, and why frontier models can silently drop information on long extraction tasks. Reducto now processes billions of pages each month, including its seven billionth page the morning of the recording. They also discuss Reducto’s R1 model, agents that can review and correct their own document extraction, and the company’s push beyond simply reading files