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Active meprin-β elevated in Alzheimer's brain and cerebrospinal fluid
Key Takeaways
- A team at the Institute for Neurosciences (IN), a joint center of Miguel Hernández University of Elche and CSIC, identified elevated meprin-β in the brain and cerebrospinal fluid of people with Alzheimer's disease.
- The study, published in Alzheimer's Research & Therapy and led by Javier Sáez Valero, measured the immature inactive form of the enzyme separately from the mature active form.
- Active meprin-β increased in more advanced Braak stages in frontal cortex samples but was not elevated in early stages of the disease.
- The authors describe the finding as evidence of a possible relationship with beta-amyloid-associated processes, not proof of a causal role, and note that BACE1 has dominated prior attention as a β-secretase.
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DT Editorial Team··via medicalxpress.com