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Epigenetic pathway offers a new model for mutation-free liver tumors
Key Takeaways
- The study describes a YAP1–TEAD–TET1 pathway in hepatocellular carcinoma without canonical driver gene mutations.
- TET1-mediated DNA demethylation activated multiple oncogenes in the reported model.
- Suppressing TET1 reduced tumor formation in mice.
- Human liver-disease data supported the pathway’s relevance, according to the source.
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DT Editorial Team··via medicalxpress.com