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GLP-1 Drugs May Ease Depression via Gut Microbiome, Mouse Study Finds
Key Takeaways
- Liraglutide accumulated in the intestine, not the brain, in stressed mice.
- Antidepressant effects persisted in mice with GLP-1 receptors knocked out.
- Depleting gut microbiota with antibiotics eliminated the antidepressant effect.
- Lactobacillus delbrueckii increased significantly and produces a precursor to the endocannabinoid 2-AG.
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DT Editorial Team··via medicalxpress.com