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Cancer Vaccines Enter a New Clinical Era
Key Takeaways
- Personalized mRNA cancer vaccines use tumor sequencing to target neoantigens unique to each patient's cancer
- Moderna/Merck mRNA-4157 showed significant melanoma recurrence reduction in Phase 2, driving broader clinical expansion
- Combination approaches pairing vaccines with checkpoint inhibitors are advancing across multiple tumor types
- Multiple Phase 3 trials now underway will determine if cancer vaccines become standard-of-care treatment
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DT Editorial Team··5 min read·via nature.com