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Lean Adipocyte Oxylipin Signaling Restrains Breast Cancer via Ferroptosis
Key Takeaways
- A study in Science (Volume 393, Issue 6816, September 2026) reports that lean adipocyte oxylipin signaling restrains breast cancer through ferroptosis.
- Adipocytes are framed as active signaling participants in the tumor microenvironment rather than passive energy stores.
- Oxylipins, oxidized lipid mediators derived from polyunsaturated fatty acids, are the proposed signaling link between adipose tissue state and tumor cell fate.
- Ferroptosis — iron-dependent, lipid-peroxidation-driven cell death — is the proposed mechanism of tumor restraint.
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DT Editorial Team··via science.org