#ferroptosis

All articles tagged with "ferroptosis"

A study in Science (Volume 393, Issue 6816, September 2026) reports that lean adipocyte oxylipin signaling restrains breast cancer through ferroptosis.
Adipocytes are framed as active signaling participants in the tumor microenvironment rather than passive energy stores.
Oxylipins, oxidized lipid mediators derived from polyunsaturated fatty acids, are the proposed signaling link between adipose tissue state and tumor cell fate.
Ferroptosis — iron-dependent, lipid-peroxidation-driven cell death — is the proposed mechanism of tumor restraint.

DT Editorial Team·Sep 13, 2026·via science.org

Huntsman Cancer Institute researchers found that obesity suppresses a biological process that kills potentially cancerous cells, offering a possible explanation for obesity's link to breast cancer.
Lean breast adipocytes produce far more of the lipid 9S-HODE than obese adipocytes, and the lipid promotes ferroptosis, a form of programmed cell death.
Senior author Keren Hilgendorf said the field has focused on how obesity promotes cancer but had not considered that it may also remove a natural protection.
The team tested whether raising 9S-HODE levels in obese preclinical mouse models could restore the tumor-suppressing signal seen in lean tissue.

DT Editorial Team·Sep 11, 2026·via medicalxpress.com